Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874358 | 0.91 | MAPK14 (0.54) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4871867 | 0.88 | TGFBR1 (0.53) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4865400 | 0.86 | TGFBR1 (0.55) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4868119 | 0.84 | MAPK14 (0.60) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL412283 | 0.83 | MAPK14 (0.53) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4869729 | 0.82 | MAPK14 (0.60) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL412808 | 0.81 | MAPK14 (0.56) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL412858 | 0.81 | MAPK14 (0.56) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4870854 | 0.81 | TGFBR1 (0.43) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4873558 | 0.78 | MAPK14 (0.67) | MAPK14EGFRRAF1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |