Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 6/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | OXTR | P30559 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870861 | 0.89 | AVPR2 (0.49) | AVPR2AVPR1AOXTRPDE4BMEN1 | |
| SCHEMBL14089575 | 0.89 | AVPR2 (0.49) | AVPR2AVPR1AOXTRMEN1KMT2A | |
| SCHEMBL4872578 | 0.84 | AVPR2 (0.52) | AVPR2PDE4BMEN1KMT2ATP53 | |
| SCHEMBL4871198 | 0.83 | LMNA (0.45) | AVPR2TP53LMNAMAPTPOLB | |
| SCHEMBL4867202 | 0.83 | AVPR2 (0.46) | AVPR2AVPR1AOXTRMEN1KMT2A | |
| SCHEMBL4870682 | 0.82 | AVPR2 (0.51) | AVPR2PDE4BMEN1KMT2ATP53 | |
| SCHEMBL4863033 | 0.80 | AVPR2 (0.48) | AVPR2AVPR1AOXTRMEN1KMT2A | |
| SCHEMBL4870210 | 0.79 | TP53 (0.53) | AVPR2AVPR1AOXTRTP53LMNA | |
| SCHEMBL4865138 | 0.78 | AVPR2 (0.46) | AVPR2AVPR1AOXTRMEN1KMT2A | |
| SCHEMBL4861652 | 0.77 | TP53 (0.47) | AVPR2AVPR1APDE4BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368444-B2 | N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-06 | — | — | US | claimed |
| EP-1475368-A1 | N-CARBAMOYL NITROGEN-CONTAINING FUSED RING COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-11-10 | — | — | EP | disclosed |