Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2351105 | 0.87 | MAP2 (0.44) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2931274 | 0.87 | MAP2 (0.44) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2930507 | 0.86 | MAP2 (0.43) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2926359 | 0.86 | MAP2 (0.46) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2927095 | 0.86 | ALDH1A1 (0.44) | MAP2GAAKDM4EEGFRHSD17B10 | |
| SCHEMBL2927126 | 0.86 | MAP2 (0.59) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2929735 | 0.84 | GAA (0.48) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2923789 | 0.84 | ALDH1A1 (0.46) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2924267 | 0.84 | MAP2 (0.41) | MAP2GAAKDM4EEGFRJAK2 | |
| SCHEMBL2925200 | 0.84 | GAA (0.49) | MAP2GAAKDM4EEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534695-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2008-06-11 | — | — | EP | disclosed |
| EP-1534695-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004014851-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-02-19 | — | — | WO | disclosed |