Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901728 | 0.93 | RAB9A (0.45) | RAB9ANPC1METCA12CA1 | |
| SCHEMBL3901723 | 0.93 | RAB9A (0.45) | RAB9ANPC1METCA12CA1 | |
| Hydrochloric Acid SCHEMBL4873202 | 0.92 | RAB9A (0.44) | RAB9ANPC1METCA12CA1 | |
| Hydrochloric Acid SCHEMBL4873207 | 0.92 | RAB9A (0.44) | RAB9ANPC1METCA12CA1 | |
| Bromide SCHEMBL4869009 | 0.92 | RAB9A (0.44) | RAB9ANPC1METCA12CA1 | |
| Bromide SCHEMBL4869013 | 0.92 | RAB9A (0.44) | RAB9ANPC1METCA12CA1 | |
| SCHEMBL3910401 | 0.88 | RAB9A (0.40) | RAB9ANPC1METCA12CA1 | |
| SCHEMBL4875526 | 0.87 | CA12 (0.39) | RAB9ANPC1CA12CA1CA2 | |
| SCHEMBL4863759 | 0.86 | CA12 (0.38) | RAB9ANPC1CA12CA1CA2 | |
| SCHEMBL4872461 | 0.85 | CA12 (0.38) | RAB9ANPC1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7431741-B2 | Brightening colorant with indolythiazolium dyes | WELLA AG (DE) | 2008-10-07 | — | — | US | claimed |
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | Wella GmbH (DE) | 2007-08-09 | — | — | US | claimed |
| EP-0761733-B1 | Rubber compositions and pneumatic tires using the same | BRIDGESTONE CORP (JP) | 2007-05-09 | — | — | EP | claimed |
| EP-1730239-B1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | WELLA AG (DE) | 2007-05-02 | — | — | EP | claimed |
| EP-1730239-A1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | Wella Aktiengesellschaft (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005080507-A1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | WELLA AKTIENGESELLSCHAFT (DE) | 2005-09-01 | — | — | WO | claimed |
| US-7431741-B2 | Brightening colorant with indolythiazolium dyes | WELLA AG (DE) | 2008-10-07 | — | — | US | disclosed |
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | Wella GmbH (DE) | 2007-08-09 | — | — | US | disclosed |
| EP-0761733-B1 | Rubber compositions and pneumatic tires using the same | BRIDGESTONE CORP (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1730239-B1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | WELLA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| EP-1730239-A1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | Wella Aktiengesellschaft (DE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005080507-A1 | LIGHTENING COLORANT CONTAINING INDOLYL THIAZOLIUM AZO DYES | WELLA AKTIENGESELLSCHAFT (DE) | 2005-09-01 | — | — | WO | disclosed |
| US-5726237-A | COMPOSITION OF A RUBBER AND CARBON BLACK HAVING LOW ROLLING RESISTANCE AND WET SKID RESISTANCE | BRIDGESTONE CORPORATION (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0761733-A2 | Rubber compositions and pneumatic tires using the same | Bridgestone Corporation (JP) | 1997-03-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070180631-A1 | Brightening colorant with indolythiazolium dyes | KRT18, TUBB1, IK | RAB9A 4591/4885NPC1 4603/4885MET 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.