Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252883 | 0.96 | TSHR (0.48) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL3251522 | 0.93 | TSHR (0.46) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL3243662 | 0.92 | MEP1B (0.46) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL4872053 | 0.91 | MEP1B (0.47) | TSHRKMT2AF2TMPRSS6FLT1 | |
| SCHEMBL3252098 | 0.90 | TSHR (0.49) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL3246588 | 0.90 | MEP1B (0.48) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL3251279 | 0.89 | KMT2A (0.48) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL4872129 | 0.89 | TSHR (0.48) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL3247678 | 0.88 | TSHR (0.53) | TSHRMAPK1KMT2AF2TMPRSS6 | |
| SCHEMBL3254822 | 0.86 | MEP1B (0.51) | TSHRMAPK1KMT2AF2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396958-B2 | Sulphonamide derivatives, their preparation and their therapeutic application | SANOFI AVENTIS (FR) | 2008-07-08 | — | — | US | disclosed |