SCHEMBL4869423 — predicted protein targets

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	IGF1R	P08069	8/20	0.87

▸	MAP2K1	Q02750	14/20	0.73

▸	MAPK3	P27361	1/20	0.71

▸	MAPK1	P28482	1/20	0.71

▸	MAP3K1	Q13233	1/20	0.71

▸	EGFR	P00533	1/20	0.59

▸	ERBB2	P04626	1/20	0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2979108	0.93	IGF1R (1.00)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
Balamapimod SCHEMBL2965207	0.89	IGF1R (0.81)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
Balamapimod SCHEMBL30104249	0.89	IGF1R (0.81)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL4443456	0.88	IGF1R (1.00)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL2962949	0.88	IGF1R (0.87)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL2974425	0.88	IGF1R (0.80)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL2963305	0.88	IGF1R (0.87)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL2971481	0.87	IGF1R (0.81)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL2968693	0.87	IGF1R (0.78)	IGF1RMAP2K1MAPK3MAPK1MAP3K1
SCHEMBL2971320	0.85	IGF1R (0.88)	IGF1RMAP2K1MAPK3MAPK1MAP3K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7449460-B2	3-Quinolinecarbonitrile protein kinase inhibitors	WYETH (US)	2008-11-11	—	—	US	disclosed