Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869591 | 0.91 | KCNA5 (0.52) | TNFNOD1MAPK1AURKAKCNA5 | |
| SCHEMBL4865901 | 0.78 | KCNH2 (0.49) | TNFNOD1MAPK1KCNA5KCNH2 | |
| SCHEMBL4867404 | 0.78 | KCNH2 (0.47) | TNFNOD1MAPK1KCNA5KCNH2 | |
| SCHEMBL4863471 | 0.78 | CDK2 (0.50) | TNFNOD1MAPK1KCNA5KCNH2 | |
| SCHEMBL27875856 | 0.78 | KCNA5 (0.69) | TNFNOD1MAPK1KCNA5KCNH2 | |
| SCHEMBL4860362 | 0.77 | KCNH2 (0.51) | TNFNOD1MAPK1KCNA5KCNH2 | |
| SCHEMBL4864910 | 0.77 | PIK3CA (0.52) | KCNA5KCNH2JAK2CDK2TYK2 | |
| SCHEMBL4862847 | 0.77 | KCNA5 (0.48) | TNFNOD1MAPK1KCNA5KCNH2 | |
| SCHEMBL4871028 | 0.76 | AURKA (0.61) | TNFNOD1MAPK1AURKAKCNA5 | |
| SCHEMBL2369019 | 0.76 | MAPK1 (1.00) | TNFNOD1MAPK1GSK3BBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456187-B2 | Furanopyrimidine compounds as potassium ion channel inhibitors | XENTION LIMITED (GB) | 2008-11-25 | — | — | US | claimed |