Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868763 | 0.82 | KCNA5 (0.49) | AURKAKMT2AMEN1KCNH2KCNA5 | |
| SCHEMBL5246200 | 0.80 | KCNH2 (0.46) | AURKAKCNH2KCNA5LMNATSHR | |
| SCHEMBL17166886 | 0.80 | POLB (0.50) | AURKATNFMAPK1NOD1KMT2A | |
| SCHEMBL3384562 | 0.77 | TNF (0.61) | AURKATNFMAPK1NOD1KMT2A | |
| SCHEMBL16945843 | 0.76 | L3MBTL1 (0.50) | AURKAKMT2ALMNATSHRHTT | |
| SCHEMBL15427127 | 0.76 | POLB (0.67) | KMT2AMEN1LMNAHTT | |
| SCHEMBL4869478 | 0.76 | TNF (0.61) | AURKATNFMAPK1NOD1KMT2A | |
| SCHEMBL4866797 | 0.74 | KCNH2 (0.52) | MAPK1KCNH2MAOAMAOBKCNA5 | |
| SCHEMBL4870568 | 0.73 | KCNA5 (0.43) | KCNH2KCNA5LMNATSHRHTT | |
| SCHEMBL3382778 | 0.72 | TNF (0.61) | AURKATNFMAPK1NOD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456187-B2 | Furanopyrimidine compounds as potassium ion channel inhibitors | XENTION LIMITED (GB) | 2008-11-25 | — | — | US | claimed |