Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | YES1 | P07947 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12190209 | 0.85 | SRC (0.56) | SRCYES1JAK2JAK3BRD4 | |
| SCHEMBL4880015 | 0.85 | AIMP2 (0.57) | SRCYES1CHRNB2CHRNA4LTA4H | |
| SCHEMBL2498311 | 0.83 | POLB (0.53) | SRCYES1JAK2JAK3BRD4 | |
| SCHEMBL2498319 | 0.83 | SRC (0.49) | SRCYES1JAK2JAK3BRD4 | |
| SCHEMBL2498478 | 0.82 | KDM4E (0.54) | SRCYES1JAK2JAK3BRD4 | |
| SCHEMBL5994756 | 0.80 | SRC (0.51) | SRCYES1CHRNB2CHRNA4LTA4H | |
| SCHEMBL5215607 | 0.79 | LTA4H (0.61) | LTA4HKDM4EALDH1A1SMN1; SMN2BACE1 | |
| SCHEMBL5995311 | 0.79 | SRC (0.54) | SRCYES1JAK2JAK3BRD4 | |
| SCHEMBL5998263 | 0.79 | LCK (0.55) | SRCYES1SYKEGFRBTK | |
| SCHEMBL5215621 | 0.78 | BACE1 (0.62) | LTA4HHRH3KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008234-A1 | 2-AMINO-5-SUBSTITUTED PYRIMIDINE INHIBITORS | TARGEGEN, INC. (US) | 2008-01-17 | — | — | WO | disclosed |