Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.32 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112384 | 0.96 | JAK2 (0.40) | JAK2BCL6EHMT2MEN1KMT2A | |
| SCHEMBL3104627 | 0.87 | NPBWR1 (0.34) | MEN1KMT2AMCHR1 | |
| SCHEMBL3112556 | 0.86 | JAK2 (0.41) | JAK2BCL6EHMT2MEN1KMT2A | |
| SCHEMBL3105707 | 0.80 | MEN1 (0.40) | JAK2EHMT2MEN1KMT2ADNMT3A | |
| SCHEMBL3109363 | 0.80 | AXL (0.42) | JAK2EHMT2MEN1KMT2ADNMT3A | |
| SCHEMBL3108855 | 0.79 | AXL (0.41) | MEN1KMT2ATLR7GPR6 | |
| SCHEMBL3104814 | 0.79 | AXL (0.42) | JAK2EHMT2MEN1KMT2ADNMT3A | |
| SCHEMBL3111443 | 0.79 | AXL (0.40) | JAK2EHMT2MEN1KMT2ADNMT3A | |
| SCHEMBL3104585 | 0.79 | JAK2 (0.39) | JAK2MEN1KMT2AMCHR1ACHE | |
| SCHEMBL3106761 | 0.78 | AOC3 (0.37) | JAK2MEN1KMT2AAOC3GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001880-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007103308-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-09-13 | — | — | WO | disclosed |