Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | CTRC | Q99895 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872435 | 0.88 | KMT2A (0.52) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL10976738 | 0.85 | MEN1 (0.56) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL27952145 | 0.85 | HDAC6 (0.54) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL10979108 | 0.85 | HDAC6 (0.54) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL10979205 | 0.84 | HDAC6 (0.56) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL16081239 | 0.83 | SIGMAR1 (0.45) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL16081233 | 0.83 | SIGMAR1 (0.45) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL10978069 | 0.83 | MEN1 (0.57) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL10983050 | 0.83 | MEN1 (0.57) | HDAC6KMT2AMEN1POLBUSP2 | |
| SCHEMBL4955033 | 0.82 | HDAC6 (0.69) | HDAC6KMT2AMEN1POLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470703-B1 | Yohimbine derivatives and use thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2008-12-30 | — | — | US | disclosed |