Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14198366 | 0.92 | TGFBR1 (0.55) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL4867319 | 0.90 | TGFBR1 (0.48) | TGFBR1THRBMAPK14TGFBR2GRM4 | |
| SCHEMBL4864349 | 0.89 | TGFBR1 (0.65) | TGFBR1THRBMAPK14TGFBR2GRM4 | |
| SCHEMBL4872902 | 0.89 | TGFBR1 (0.65) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL4871905 | 0.89 | TGFBR1 (0.60) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL407982 | 0.88 | TGFBR1 (0.60) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL4868276 | 0.88 | TGFBR1 (0.53) | TGFBR1THRBMAPK14TGFBR2GRM4 | |
| SCHEMBL413616 | 0.88 | TGFBR1 (0.64) | TGFBR1TGFBR2 | |
| SCHEMBL411839 | 0.88 | TGFBR1 (0.67) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL4872764 | 0.88 | TGFBR1 (0.59) | TGFBR1THRBMAPK14TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |