SCHEMBL487310

SCHEMBL487310

OCCCC#Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.50
CYP3A4 P08684 3/20 0.50
CYP2C9 P11712 3/20 0.50
CYP2C19 P33261 3/20 0.50
ALDH1A1 P00352 2/20 0.50
MAPT P10636 2/20 0.50
KDM4E B2RXH2 2/20 0.50
THPO P40225 1/20 0.50
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
APP P05067 1/20 0.46
HRH3 Q9Y5N1 1/20 0.46
GABRP O00591 1/20 0.45
GABRD O14764 1/20 0.45
GABRA1 P14867 1/20 0.45
GABRB1 P18505 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2947602 0.94 CYP1A2 (0.58) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL23014997 0.92 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL4948108 0.92 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL3311223 0.88 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL5808117 0.86 CYP1A2 (0.54) CYP1A2CYP3A4CYP2C9CYP2C19KDM4E
SCHEMBL17911731 0.86 CYP1A2 (0.58) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL10454358 0.86 CYP1A2 (0.42) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL2180350 0.85 HTR2C (0.51) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL18453785 0.84 KDM4E (0.52) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL23015036 0.82 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115557836-A Preparation method of carboxylic acid 云南大学 2023-01-03 CN claimed
US-11339174-B2 γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2022-05-24 US claimed
US-20210198273-A1 GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2021-07-01 US claimed
EP-3619214-A1 GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF Council of Scientific and Industrial Research (IN) 2020-03-11 EP claimed
WO-2018203346-A1 γ-SPIROKETAL- γ –LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2018-11-08 WO claimed
US-7727692-B2 Electrophotographic photoreceptor, image forming apparatus, and process cartridge FUJI XEROX CO., LTD. (JP) 2010-06-01 US claimed
EP-4711424-A1 AQUEOUS INK COMPOSITION FOR WRITING UTENSILS, AND WRITING UTENSIL OBTAINED USING SAME MITSUBISHI PENCIL COMPANY, LIMITED (JP) 2026-03-18 EP disclosed
US-12415770-B2 Modulators of liver receptor homologue 1 (LRH-1) and uses Emory University, Office of Technology Transfer (US) 2025-09-16 US disclosed
EP-4516774-A2 MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES Emory University (US) 2025-03-05 EP disclosed
EP-3595652-B1 MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) UNIV EMORY (US) 2024-12-04 EP disclosed
WO-2024237160-A1 AQUEOUS INK COMPOSITION FOR WRITING UTENSILS, AND WRITING UTENSIL OBTAINED USING SAME 三菱鉛筆株式会社 2024-11-21 WO disclosed
US-20240368066-A1 MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES EMORY UNIVERSITY 2024-11-07 US disclosed
US-12065402-B2 Modulators of liver receptor homologue 1 (LRH-1) and uses EMORY UNIVERSITY (US) 2024-08-20 US disclosed
US-20060079533-A1 Methods of treating alzheimer's disease NIEMAN JAMES A 2006-04-13 US disclosed
WO-2002076440-A2 METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES ELAN PHARMACEUTICALS, INC. (US) 2002-10-03 WO disclosed
US-6051712-A PREVENTION OF HIGH BLOOD PRESSURE AND CARDIAC INSUFFICIENCY, AS WELL AS GLAUCOMA, CARDIAC INFARCT, KIDNEY INSUFFICIENCY AND RESTENOSIS HOFFMANN-LA ROCHE INC. (US) 2000-04-18 US disclosed
EP-0111105-B1 UNSATURATED AROMATIC AMIDES AS PESTICIDES THE WELLCOME FOUNDATION LIMITED (GB) 1990-12-05 EP disclosed
US-4931469-A APPLYING UNSATURATED PHENYL AMIDES; FOR ACARINA BURROUGHS WELLCOME CO. (US) 1990-06-05 US disclosed
US-4855086-A MITICIDES, INSECTICIDES BURROUGHS WELLCOME CO. (US) 1989-08-08 US disclosed
EP-0111105-A2 Unsaturated aromatic amides as pesticides THE WELLCOME FOUNDATION LIMITED (GB) 1984-06-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240368066-A1 MODULATORS OF LIVER RECEPTOR HOMOLOGUE 1 (LRH-1) AND USES NR1H2, NR1H3, NR1H4 CYP1A2 1442/4885CYP3A4 2300/4885CYP2C9 3060/4885
US-12415770-B2 Modulators of liver receptor homologue 1 (LRH-1) and uses NR1H2, NR1H3, NR1H4 CYP1A2 1442/4885CYP3A4 2300/4885CYP2C9 3060/4885
US-11339174-B2 γ-spiroketal-γ-lactones and pharmaceutical composition containing same and process for preparation thereof HSD17B7, PKD1, CYP17A1 CYP1A2 582/4885CYP3A4 183/4885CYP2C9 211/4885
US-12065402-B2 Modulators of liver receptor homologue 1 (LRH-1) and uses NR1H2, NR1H3, NR1H4 CYP1A2 1442/4885CYP3A4 2300/4885CYP2C9 3060/4885
US-20060079533-A1 Methods of treating alzheimer's disease BACE1, PSEN1, PSEN2 CYP1A2 3010/4885CYP3A4 3733/4885CYP2C9 4338/4885
US-20210198273-A1 GAMMA-SPIROKETAL-GAMMA-LACTONES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PROCESS FOR PREPARATION THEREOF HSD17B7, PKD1, CYP17A1 CYP1A2 570/4885CYP3A4 197/4885CYP2C9 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.