Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CSGALNACT1 | Q8TDX6 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | ACR | P10323 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869419 | 0.91 | MAPT (0.60) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL4873849 | 0.89 | MAPT (0.61) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL5150469 | 0.82 | MAPT (0.75) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL4872988 | 0.82 | CYP1A2 (0.54) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL5693625 | 0.81 | RAB9A (0.45) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL5182393 | 0.80 | MAPT (0.65) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL4869583 | 0.80 | MAPT (0.45) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL3798740 | 0.80 | MAPT (0.58) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL5150504 | 0.79 | MAPT (0.52) | MAPTALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL5150494 | 0.79 | MAPT (0.66) | MAPTALDH1A1KDM4EPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326790-B2 | Diphenylisoxazole compounds and hydro isomers thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | claimed |