Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.60 |
| ▸ | CHUK | O15111 | 4/20 | 0.60 |
| ▸ | TAF1 | P21675 | 2/20 | 0.56 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.52 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | BRD2 | P25440 | 1/20 | 0.50 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.50 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.50 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.50 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.50 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857035 | 0.89 | IKBKB (0.64) | IKBKBCHUKNEK1RIPK1LRRK2 | |
| SCHEMBL857458 | 0.88 | IKBKB (0.63) | IKBKBCHUKNEK1RIPK1LRRK2 | |
| SCHEMBL1718801 | 0.88 | PRKCI (0.63) | IKBKBCHUKTAF1NEK1RIPK1 | |
| SCHEMBL30009173 | 0.86 | JAK1 (0.61) | IKBKBCHUKNEK1LRRK2AURKB | |
| SCHEMBL30009546 | 0.84 | JAK1 (0.65) | TAF1LRRK2AURKBJAK2MAP4K4 | |
| SCHEMBL16625847 | 0.84 | MKNK1 (0.61) | TAF1LRRK2PRKCIPIK3CACYP3A4 | |
| SCHEMBL30009468 | 0.83 | JAK1 (0.63) | IKBKBCHUKNEK1AURKBAURKA | |
| SCHEMBL21954784 | 0.81 | TAF1 (0.54) | TAF1RIPK1LRRK2BRD9TRIM24 | |
| SCHEMBL4830288 | 0.80 | NEK1 (0.58) | IKBKBCHUKNEK1LRRK2AURKB | |
| SCHEMBL12605425 | 0.80 | SMN1; SMN2 (0.52) | LRRK2AURKBAURKAJAK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208053-A1 | Fused heterobicyclic kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2007-09-06 | — | — | US | claimed |
| EP-1979353-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| US-20070208053-A1 | Fused heterobicyclic kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2007-09-06 | — | — | US | disclosed |
| US-20070208053-A1 | Fused heterobicyclic kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2007-09-06 | — | — | US | disclosed |
| US-20070208053-A1 | Fused heterobicyclic kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2007-09-06 | — | — | US | disclosed |
| WO-2007084667-A2 | FUSED HETEROBICYCLIC KINASE INHIBITORS | OSI PHARMACEUTICAL, INC. (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208053-A1 | Fused heterobicyclic kinase inhibitors | MAP2K5, MAP2K7, MAP2K2 | IKBKB 138/4885CHUK 31/4885TAF1 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.