Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 15/20 | 0.61 |
| ▸ | MKNK2 | Q9HBH9 | 15/20 | 0.61 |
| ▸ | EIF4E | P06730 | 5/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16626044 | 0.90 | MKNK1 (0.62) | MKNK1MKNK2EIF4ECHEK1PIK3CA | |
| SCHEMBL16620611 | 0.85 | MKNK1 (0.53) | MKNK1MKNK2EIF4ECHEK1PIK3CA | |
| SCHEMBL4873430 | 0.84 | IKBKB (0.60) | PIK3CACYP3A4PRKCITAF1LRRK2 | |
| SCHEMBL16304077 | 0.79 | MKNK1 (0.78) | MKNK1MKNK2EIF4ECYP3A4FYN | |
| SCHEMBL17998738 | 0.79 | MKNK1 (0.52) | MKNK1MKNK2EIF4ECYP3A4TAF1 | |
| SCHEMBL16621060 | 0.77 | MKNK1 (0.50) | MKNK1MKNK2EIF4ECYP3A4TAF1 | |
| SCHEMBL22689133 | 0.77 | MKNK1 (0.68) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL16620475 | 0.77 | MKNK1 (0.68) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL16626028 | 0.76 | MKNK1 (0.53) | MKNK1MKNK2EIF4ECYP3A4 | |
| SCHEMBL29756282 | 0.76 | MKNK1 (0.51) | MKNK1MKNK2EIF4ECYP3A4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050505-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-09 | — | — | WO | disclosed |