Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNH3 | Q9ULD8 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313156 | 0.84 | TDP1 (0.67) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL22648059 | 0.78 | TDP1 (0.54) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL632551 | 0.76 | TDP1 (0.56) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL31174454 | 0.76 | TDP1 (0.56) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL9312188 | 0.76 | TDP1 (0.56) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL4974177 | 0.75 | — | — | |
| SCHEMBL7473537 | 0.74 | CA1 (0.55) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL8359919 | 0.74 | TDP1 (0.54) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL7738343 | 0.74 | TDP1 (0.54) | TDP1ALDH1A1LMNACYP3A4THRB | |
| SCHEMBL632883 | 0.74 | CA12 (0.55) | TDP1ALDH1A1LMNACYP3A4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106079-B2 | Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same | SANKYO COMPANY, LIMITED (JP) | 2012-01-31 | — | — | US | disclosed |
| US-7816552-B2 | Intermediate of 6-substituted 1-methyl-1-H-benzimidazole derivative and method for producing same | SANKYO COMPANY, LIMITED (JP) | 2010-10-19 | — | — | US | disclosed |
| US-20100234612-A1 | Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same | SANKYO COMPANY, LIMITED (JP) | 2010-09-16 | — | — | US | disclosed |
| US-20090023929-A1 | Intermediate of 6-Substituted 1-Methyl-1-H-Benzimidazole Derivative and Method for Producing Same | SANKYO COMPANY, LIMITED (JP) | 2009-01-22 | — | — | US | disclosed |
| CN-101068770-A | Process for producing 6-substituted-1-methyl-1-H-benzimidazole derivative and synthetic intermediate therefor | SANKYO CO (JP) | 2007-11-07 | — | — | CN | disclosed |
| EP-1798216-A1 | INTERMEDIATE OF 6-SUBSTITUTED-1-METHYL-1-H-BENZIMIDAZOLE DERIVATIVE AND METHOD FOR PRODUCING SAME | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023929-A1 | Intermediate of 6-Substituted 1-Methyl-1-H-Benzimidazole Derivative and Method for Producing Same | AZI2, CYC1, CCNI | TDP1 2994/4885ALDH1A1 928/4885LMNA 1690/4885 |
| US-20100234612-A1 | Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same | CYC1, CYP2B6, COX6B1 | TDP1 3676/4885ALDH1A1 668/4885LMNA 3284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.