Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31174454 | 1.00 | TDP1 (0.56) | TDP1KCNH3POLBMAPTCYP3A4 | |
| SCHEMBL9313156 | 0.85 | TDP1 (0.67) | TDP1KCNH3POLBMAPTCYP3A4 | |
| SCHEMBL10996019 | 0.83 | MAPT (0.50) | KCNH3POLBMAPTCYP3A4NPSR1 | |
| SCHEMBL1004460 | 0.83 | MAPT (0.50) | KCNH3POLBMAPTCYP3A4NPSR1 | |
| SCHEMBL28679508 | 0.80 | MAPT (0.52) | KCNH3POLBMAPTCYP3A4NPSR1 | |
| SCHEMBL27560495 | 0.80 | MAPT (0.52) | MAPTCYP3A4NPSR1CYP1A2CYP2D6 | |
| SCHEMBL19914819 | 0.79 | MAPT (0.47) | KCNH3POLBMAPTCYP3A4NPSR1 | |
| SCHEMBL7025738 | 0.79 | CYP3A4 (0.57) | TDP1KCNH3POLBMAPTCYP3A4 | |
| SCHEMBL11526055 | 0.79 | MAPT (0.50) | KCNH3POLBMAPTCYP3A4NPSR1 | |
| SCHEMBL11310422 | 0.79 | MAPT (0.47) | KCNH3POLBMAPTCYP3A4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007016190-A2 | ANTIPARKINSONIAN ACTION OF PHENYLISOPROPYLAMINES | DUKE UNIVERSITY (US) | 2007-02-08 | — | — | WO | claimed |
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | claimed |
| JP-59167545-A | — | — | None | — | — | JP | disclosed |
| US-12358886-B2 | Heterocyclic compounds for use in the treatment of cancer | ARTIOS PHARMA LIMITED (GB) | 2025-07-15 | — | — | US | disclosed |
| CN-114667167-B | Heterocyclic compounds for the treatment of cancer | 阿提奥斯医药有限公司 | 2024-12-20 | — | — | CN | disclosed |
| WO-2024215870-A2 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF POLYMERASE THETA AND METHODS OF USE THEREOF | 1CBIO, INC. (US) | 2024-10-17 | — | — | WO | disclosed |
| EP-4010080-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LTD (GB) | 2023-09-27 | — | — | EP | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| US-20230242503-A9 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-08-03 | — | — | US | disclosed |
| US-5929235-A | Aromatic tertiary amine compound having benzazepine structures | FUJI PHOTO FILM CO., LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| US-5001263-A | Formation of ortho-alkylated aromatic amines from N-alkylated aromatic amines | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1991-03-19 | — | — | US | disclosed |
| EP-0066325-B1 | PROCESS FOR THE PREPARATION OF ANILINE DERIVATIVES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1985-07-17 | — | — | EP | disclosed |
| JP-S59167545-A | PRODUCTION OF 3-METHYL-4-ISOPROPYLANILINE | NIPPON KAYAKU CO LTD | 1984-09-21 | — | — | JP | disclosed |
| EP-0066325-A1 | Process for the preparation of aniline derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1982-12-08 | — | — | EP | disclosed |
| EP-0018576-B1 | PROCESS FOR THE PREPARATION OF N-ALKYLATED AROMATIC AMINES | BAYER AG (DE) | 1982-04-28 | — | — | EP | disclosed |
| US-4322492-A | Process for the development of color photographic images with p-dialkylaminoaniline color developers | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1982-03-30 | — | — | US | disclosed |
| US-4268458-A | Process for the preparation of N-alkylated aromatic amines | BAYER AKTIENGESELLSCHAFT (DE) | 1981-05-19 | — | — | US | disclosed |
| EP-0018576-A1 | Process for the preparation of N-alkylated aromatic amines | BAYER AG (DE) | 1980-11-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | TDP1 716/4885KCNH3 479/4885POLB 1486/4885 |
| US-20230242503-A9 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | SDHA, SDHB, NQO1 | TDP1 1437/4885KCNH3 4089/4885POLB 356/4885 |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | EIF4E, EIF4EBP1, EIF4A1 | TDP1 1025/4885KCNH3 4412/4885POLB 1778/4885 |
| US-12358886-B2 | Heterocyclic compounds for use in the treatment of cancer | SDHA, DPYD, TP53 | TDP1 1207/4885KCNH3 3987/4885POLB 459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.