Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.58 |
| ▸ | F2RL1 | P55085 | 15/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698055 | 1.00 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL697224 | 0.88 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL3532392 | 0.86 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL13034019 | 0.86 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL700615 | 0.86 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL698140 | 0.82 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL1573055 | 0.82 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CF2RL1TAAR1 | |
| SCHEMBL714299 | 0.81 | F2RL1 (0.59) | F2RL1 | |
| SCHEMBL955822 | 0.81 | F2RL1 (0.49) | ADRA2AADRA2BADRA2CF2RL1 | |
| Demiditraz SCHEMBL696353 | 0.78 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CF2RL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981880-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085556-A2 | USE OF 4-IMIDAZOLE DERIVATIVES FOR CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |