Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 12/20 | 0.54 |
| ▸ | AURKA | O14965 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | KIT | P10721 | 5/20 | 0.54 |
| ▸ | TEK | Q02763 | 3/20 | 0.54 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | LYN | P07948 | 4/20 | 0.51 |
| ▸ | FLT4 | P35916 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | BLK | P51451 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3534336 | 0.85 | PTK2 (0.61) | EPHB4KITMAPK14BRAFPTK2 | |
| SCHEMBL4877521 | 0.84 | PI4KA (0.45) | EPHB4EPHA3KDRAURKAAURKB | |
| SCHEMBL4868939 | 0.83 | KDR (0.61) | EPHB4EPHA3KDRAURKAAURKB | |
| SCHEMBL3532285 | 0.81 | PTK2 (0.67) | EPHB4MAPK14BRAFNTRK1NTRK2 | |
| SCHEMBL4873848 | 0.78 | PI4KA (0.48) | KDRAURKAAURKBKITTEK | |
| SCHEMBL3834274 | 0.77 | KDR (0.57) | EPHB4EPHA3KDRAURKAAURKB | |
| SCHEMBL3528532 | 0.76 | PTK2 (0.65) | EPHB4KITMAPK14PTK2ABL1 | |
| SCHEMBL3530565 | 0.76 | PTK2 (0.67) | EPHB4MAPK14PTK2MAPK13MAPK12 | |
| SCHEMBL3536548 | 0.75 | PTK2 (0.74) | EPHB4MAPK14PTK2MAPK13MAPK12 | |
| SCHEMBL13193104 | 0.75 | CSF1R (0.69) | KDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-09-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | TIE1, FLT1, RET | EPHB4 176/4885EPHA3 173/4885KDR 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.