Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 8/20 | 0.40 |
| ▸ | TEK | Q02763 | 5/20 | 0.40 |
| ▸ | CSF1R | P07333 | 5/20 | 0.39 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | FLT1 | P17948 | 3/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | BLK | P51451 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4877521 | 0.79 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL4873824 | 0.78 | EPHB4 (0.56) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL3532354 | 0.77 | PTK2 (0.66) | PTK2PTK2BFLT3 | |
| SCHEMBL3536548 | 0.75 | PTK2 (0.74) | PTK2PTK2B | |
| SCHEMBL3530565 | 0.74 | PTK2 (0.67) | PTK2PTK2B | |
| SCHEMBL3532285 | 0.74 | PTK2 (0.67) | PTK2PTK2BNTRK2 | |
| SCHEMBL3536896 | 0.73 | PTK2 (0.46) | PI4KAPI4K2BPI4K2API4KBPTK2 | |
| SCHEMBL3528532 | 0.73 | PTK2 (0.65) | PTK2PTK2BKIT | |
| SCHEMBL3531554 | 0.72 | PTK2 (0.64) | PTK2PTK2B | |
| SCHEMBL3534336 | 0.71 | PTK2 (0.61) | PTK2PTK2BKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-09-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | TIE1, FLT1, RET | PI4KA 457/4885PI4K2B 620/4885PI4K2A 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.