Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 10/20 | 0.47 |
| ▸ | UCHL1 | P09936 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22315139 | 0.88 | USP30 (0.52) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL4904764 | 0.86 | USP30 (0.46) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL26364475 | 0.83 | USP30 (0.48) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL3182755 | 0.81 | PDK2 (0.47) | USP30NPC1MEN1KMT2A | |
| SCHEMBL26364434 | 0.80 | USP30 (0.51) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL26364450 | 0.80 | USP30 (0.51) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL26364407 | 0.80 | USP30 (0.51) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL3835668 | 0.76 | USP30 (0.55) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL26364656 | 0.75 | MEN1 (0.47) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL26364458 | 0.75 | MEN1 (0.47) | USP30UCHL1LMNANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890696-A2 | NOVEL 3-SPIROCYCLIC INDOLYL DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006130416-A2 | NOVEL 3-SPIROCYCLIC INDOLYL DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |