Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 10/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875392 | 0.86 | USP30 (0.47) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL3179424 | 0.81 | NPC1 (0.51) | USP30NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL22315139 | 0.77 | USP30 (0.52) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL27730506 | 0.74 | PDK2 (0.38) | USP30NPC1ALDH1A1RAB9AMAPT | |
| SCHEMBL3835668 | 0.74 | USP30 (0.55) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL28618685 | 0.73 | USP30 (0.52) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL26364475 | 0.73 | USP30 (0.48) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL28151987 | 0.73 | USP30 (0.52) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL5427850 | 0.72 | HSD17B10 (0.52) | USP30UCHL1LMNANPSR1NPC1 | |
| SCHEMBL5427853 | 0.72 | HSD17B10 (0.52) | USP30UCHL1LMNANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890696-A2 | NOVEL 3-SPIROCYCLIC INDOLYL DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006130416-A2 | NOVEL 3-SPIROCYCLIC INDOLYL DERIVATIVES USEFUL AS ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-12-07 | — | — | WO | disclosed |