Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40263 | 0.82 | — | — | |
| Acetic Acid SCHEMBL297447 | 0.80 | — | — | |
| Acetic Acid SCHEMBL27505116 | 0.79 | — | — | |
| Acetic Acid SCHEMBL574619 | 0.78 | FFAR3 (0.64) | FFAR3LCKFYNTP53TSHR | |
| Acetic Acid SCHEMBL174567 | 0.78 | — | — | |
| Acetic Acid SCHEMBL9659096 | 0.78 | FFAR3 (0.64) | FFAR3LCKFYNTP53TSHR | |
| Acetic Acid SCHEMBL28843588 | 0.78 | FFAR3 (0.64) | FFAR3LCKFYNTP53TSHR | |
| Acetic Acid SCHEMBL18528147 | 0.78 | — | — | |
| Acetic Acid SCHEMBL28284893 | 0.76 | FFAR3 (0.50) | FFAR3LCKFYNTP53TSHR | |
| Acetic Acid SCHEMBL27469271 | 0.76 | FFAR3 (0.50) | FFAR3LCKFYNTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071909-B1 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INST OF TECHN (US) | 2014-01-22 | — | — | EP | disclosed |
| US-8597549-B2 | Two-photon or higher-order absorbing optical materials for generation of reactive species | THE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-12-03 | — | — | US | disclosed |
| US-20080283804-A1 | include a bridge of pi-conjugated bonds connecting electron donating or accepting groups; electronically excited upon absorption lead to formation of Lewis acidic species, Lewis basic species, radical species or ionic species; chromogens use in engineering, biological, and medicinal field | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2008-11-20 | — | — | US | disclosed |
| US-7235194-B2 | Two-photon or higher-order absorbing optical materials for generation of reactive species | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1071909-A4 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INST OF TECHN (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040110984-A1 | Two-photon or higher-order absorbing optical materials for generation of reactive species | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2004-06-10 | — | — | US | disclosed |
| US-6608228-B1 | Fluorenyl and dibenzosuberenyl moieties; efficient | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-08-19 | — | — | US | disclosed |
| EP-1071909-A1 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999053242-A1 | TWO-PHOTON OR HIGHER-ORDER ABSORBING OPTICAL MATERIALS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110984-A1 | Two-photon or higher-order absorbing optical materials for generation of reactive species | SLC43A1, SLC7A1, SLC7A5 | FFAR3 2936/4885LCK 4120/4885FYN 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.