Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870999 | 0.91 | CYP1A2 (0.41) | CYP1A2POLB | |
| SCHEMBL4871012 | 0.89 | CYP1A2 (0.39) | CYP1A2POLB | |
| SCHEMBL14269718 | 0.87 | CYP1A2 (0.38) | CYP1A2POLB | |
| SCHEMBL14448375 | 0.72 | CYP1A2 (0.40) | CYP1A2POLB | |
| SCHEMBL14676305 | 0.70 | KDM4C (0.30) | KDM4C | |
| SCHEMBL4677460 | 0.62 | CA2 (0.38) | KDM4C | |
| SCHEMBL14531385 | 0.61 | CYP1A2 (0.39) | CYP1A2POLB | |
| SCHEMBL1604427 | 0.61 | CYP1A2 (0.39) | CYP1A2POLB | |
| SCHEMBL1605102 | 0.61 | CYP1A2 (0.39) | CYP1A2POLB | |
| SCHEMBL14441052 | 0.60 | POLB (0.39) | POLBKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7241893-B2 | Thiazolinone 2-substituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241893-B2 | Thiazolinone 2-substituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241893-B2 | Thiazolinone 2-substituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1791836-A1 | THIAZOLINONE 2-SUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| EP-1765817-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| US-20060063804-A1 | Thiazolinone 2-substituted quinolines | CHEN LI | 2006-03-23 | — | — | US | disclosed |
| WO-2006029863-A1 | THIAZOLINONE 2-SUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |
| WO-2006002829-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| US-20060004045-A1 | Thiazolinone unsubstituted quinolines | CHEN LI | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063804-A1 | Thiazolinone 2-substituted quinolines | CDK1, CDK17, CDK12 | CYP1A2 3135/4885POLB 642/4885KDM4C 1388/4885 |
| US-20060004045-A1 | Thiazolinone unsubstituted quinolines | CDK1, CDK17, CDK14 | CYP1A2 3432/4885POLB 707/4885KDM4C 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.