Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 5/20 | 0.33 |
| ▸ | CNR1 | P21554 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27962714 | 0.86 | SOAT1 (0.38) | SOAT1FFAR3CNR2CNR1PPARG | |
| Hydrogen Peroxide SCHEMBL28051253 | 0.85 | — | — | |
| Glycine SCHEMBL27846420 | 0.84 | GLRA1 (0.43) | LMNASOAT1CNR2CNR1PPARG | |
| Acetic Acid SCHEMBL330176 | 0.84 | CNR2 (0.37) | SOAT1FFAR3CNR2CNR1PPARG | |
| Stearic Acid SCHEMBL715877 | 0.83 | FASN (0.64) | LMNAFASNPPARGMAPTOR51E2 | |
| Stearic Acid SCHEMBL1071278 | 0.83 | FASN (0.64) | LMNAFASNPPARGMAPTOR51E2 | |
| Dodecanoate SCHEMBL714246 | 0.83 | FASN (0.64) | LMNAFASNPPARGMAPTOR51E2 | |
| Palmitic Acid SCHEMBL3250351 | 0.83 | FASN (0.64) | LMNAFASNPPARGMAPTOR51E2 | |
| SCHEMBL13892466 | 0.83 | — | — | |
| SCHEMBL734653 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140341909-A1 | CONJUGATION OF BIOMOLECULES USING DIELS-ALDER CYCLOADDITION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2014-11-20 | — | — | US | disclosed |
| US-20080008709-A1 | Conjugation of biomolecules using Diels-Alder cycloaddition | The Government of the U.S. as represented by the Secretary of the Dept. of Health and Human | 2008-01-10 | — | — | US | disclosed |
| US-7211445-B2 | Immunology, diagnosis, therapy; complex of carbohydrate and protein; immobilization | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-05-01 | — | — | US | disclosed |
| US-20040082067-A1 | Immunology, diagnosis, therapy; complex of carbohydrate and protein; immobilization | THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HLTH. AND HUMAN SERVICE | 2004-04-29 | — | — | US | disclosed |
| US-6673905-B2 | FOR COVALENTLY LINKING CARBOHYDRATES AND PROTEINS UNDER NEUTRAL CONDITIONS, BY ATTACHING DOUBLE BONDS TO A CARRIER PROTEIN, AND ATTACHING A CONJUGATED DIENE TO A CARBOHYDRATE HAPTEN, THEN COUPLING; VACCINES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2004-01-06 | — | — | US | disclosed |
| US-20020068818-A1 | Conjugation of biomolecules using diels-alder cycloaddition | POZSGAY VINCE (US) | 2002-06-06 | — | — | US | disclosed |
| US-20020051788-A1 | For covalently linking carbohydrates and proteins under neutral conditions, by attaching double bonds to a carrier protein, and attaching a conjugated diene to a carbohydrate hapten, then coupling; vaccines | HEALTH AND HUMAN SERVICES, DEPARTMENT OF, GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, THE | 2002-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140341909-A1 | CONJUGATION OF BIOMOLECULES USING DIELS-ALDER CYCLOADDITION | DERA, DCLRE1A, CD2BP2 | LMNA 2915/4885EGLN1 3428/4885ALKBH5 3149/4885 |
| US-20020068818-A1 | Conjugation of biomolecules using diels-alder cycloaddition | DERA, DCLRE1A, CD2BP2 | LMNA 2915/4885EGLN1 3428/4885ALKBH5 3149/4885 |
| US-20020051788-A1 | For covalently linking carbohydrates and proteins under neutral conditions, by attaching double bonds to a carrier protein, and attaching a conjugated diene to a carbohydrate hapten, then coupling; vaccines | DCLRE1A, DERA, LY96 | LMNA 1314/4885EGLN1 2753/4885ALKBH5 3021/4885 |
| US-20080008709-A1 | Conjugation of biomolecules using Diels-Alder cycloaddition | DERA, DCLRE1A, CD2BP2 | LMNA 2915/4885EGLN1 3428/4885ALKBH5 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.