Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.37 |
| ▸ | CNR1 | P21554 | 7/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27962714 | 0.98 | SOAT1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 | |
| SCHEMBL330063 | 0.87 | — | — | |
| SCHEMBL3227143 | 0.87 | ALDH1A1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 | |
| SCHEMBL3230993 | 0.87 | ALDH1A1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 | |
| SCHEMBL3230987 | 0.87 | ALDH1A1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 | |
| SCHEMBL418718 | 0.87 | — | — | |
| SCHEMBL330064 | 0.87 | — | — | |
| SCHEMBL3784577 | 0.87 | ALDH1A1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 | |
| SCHEMBL3784576 | 0.87 | ALDH1A1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 | |
| SCHEMBL3791597 | 0.87 | ALDH1A1 (0.38) | CNR2CNR1SOAT1ALDH1A1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041459-B1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | GIULIANI SPA (IT) | 2019-04-03 | — | — | EP | claimed |
| EP-2593097-B1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2016-08-24 | — | — | EP | claimed |
| EP-3041459-A1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | Giuliani S.p.A. (IT) | 2016-07-13 | — | — | EP | claimed |
| WO-2015033276-A1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | GIULIANI S.P.A. (IT) | 2015-03-12 | — | — | WO | claimed |
| EP-2593097-A1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | Giuliani S.p.A. (IT) | 2013-05-22 | — | — | EP | claimed |
| US-20130108564-A1 | Compounds with a Skin Pigmenting Activity And Pharmaceutical or Cosmetic Compositions Containing Them | GIULIANI S.P.A. (IT) | 2013-05-02 | — | — | US | claimed |
| WO-2012007572-A1 | COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2012-01-19 | — | — | WO | claimed |
| EP-2407163-A1 | Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them | Giuliani S.p.A. (IT) | 2012-01-18 | — | — | EP | claimed |
| EP-3041459-B1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | GIULIANI SPA (IT) | 2019-04-03 | — | — | EP | disclosed |
| EP-2384191-B1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI SPA (IT) | 2018-07-18 | — | — | EP | disclosed |
| US-9597295-B2 | Diene compounds for use in human epidermal cell repair, and pharmaceutical and cosmetic compositions containing them | GIULIANI S.P.A. (IT) | 2017-03-21 | — | — | US | disclosed |
| US-20160213635-A1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | GIULIANI S.P.A. (IT) | 2016-07-28 | — | — | US | disclosed |
| EP-3041459-A1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | Giuliani S.p.A. (IT) | 2016-07-13 | — | — | EP | disclosed |
| WO-2015033276-A1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | GIULIANI S.P.A. (IT) | 2015-03-12 | — | — | WO | disclosed |
| US-20130150443-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2013-06-13 | — | — | US | disclosed |
| EP-2384191-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Giuliani S.p.A. (IT) | 2011-11-09 | — | — | EP | disclosed |
| US-20110224298-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2011-09-15 | — | — | US | disclosed |
| WO-2010052328-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GIULIANI S.P.A. (IT) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224298-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | KRT18, CKS2, MKI67 | CNR2 1653/4885CNR1 1496/4885SOAT1 3000/4885 |
| US-20160213635-A1 | COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER | PKLR, AKR1C3, HK1 | CNR2 1911/4885CNR1 1770/4885SOAT1 4038/4885 |
| US-20130108564-A1 | Compounds with a Skin Pigmenting Activity And Pharmaceutical or Cosmetic Compositions Containing Them | TYR, MC1R, HK1 | CNR2 2553/4885CNR1 2572/4885SOAT1 1059/4885 |
| US-20130150443-A1 | DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | KRT18, MMS19, CKS2 | CNR2 1722/4885CNR1 1505/4885SOAT1 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.