SCHEMBL4877129

SCHEMBL4877129

O=C(Nc1ccc(N2CCO/C2=N\O)cc1)c1nccnc1C(=O)Nc1ccc(Cl)cn1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F10 P00742 5/20 0.44
RAB9A P51151 6/20 0.41
SMN1; SMN2 Q16637 5/20 0.41
NPC1 O15118 4/20 0.41
NAMPT P43490 1/20 0.41
KMT2A Q03164 4/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 1/20 0.39
ALOX15 P16050 1/20 0.38
MEN1 O00255 1/20 0.38
TSHR P16473 1/20 0.38
ABCB1 P08183 1/20 0.38
BRD4 O60885 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4877139 1.00 F10 (0.44) F10RAB9ASMN1; SMN2NPC1NAMPT
SCHEMBL4710687 0.87 F10 (0.47) F10RAB9ASMN1; SMN2NPC1NAMPT
SCHEMBL4878211 0.87 F10 (0.47) F10RAB9ASMN1; SMN2NPC1NAMPT
Hydrochloric Acid SCHEMBL4886675 0.87 F10 (0.46) F10RAB9ASMN1; SMN2NPC1NAMPT
Bromide SCHEMBL4885344 0.87 F10 (0.46) F10RAB9ASMN1; SMN2NPC1NAMPT
SCHEMBL4884191 0.83 F10 (0.45) F10RAB9ASMN1; SMN2NPC1NAMPT
SCHEMBL4709461 0.82 F10 (0.62) F10
SCHEMBL8259831 0.82 F10 (0.43) F10RAB9ASMN1; SMN2NPC1NAMPT
SCHEMBL4712810 0.80 KDM1A (0.52) F10RAB9ASMN1; SMN2NPC1LMNA
SCHEMBL4710018 0.79 F10 (0.58) F10RAB9ASMN1; SMN2NPC1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
WO-2006058630-A1 CYCLIC IMINOCARBAMATES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2006-06-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214533-A1 Cyclic Iminocarbamates And Their Use F2, UQCRB, F12 F10 26/4885RAB9A 2655/4885SMN1; SMN2 2534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.