Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.43 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868863 | 0.81 | HRH4 (0.42) | HRH4NPC1ADORA2AACHEBCHE | |
| SCHEMBL2167222 | 0.81 | HRH4 (0.57) | HRH4NPC1NPY5RADORA2AACHE | |
| SCHEMBL4878269 | 0.80 | HRH4 (0.55) | HRH4NPY5REPHA4ACHEBCHE | |
| SCHEMBL4876581 | 0.78 | HRH4 (0.54) | HRH4NPC1ADORA2AACHEBCHE | |
| SCHEMBL606792 | 0.77 | HRH4 (1.00) | HRH4NPY5RHRH2HRH3 | |
| SCHEMBL29624015 | 0.75 | TYMS (0.58) | HRH4NPY5REPHA4TYMS | |
| SCHEMBL604878 | 0.75 | HRH4 (0.74) | HRH4HRH2HRH3 | |
| SCHEMBL4874612 | 0.75 | HRH4 (0.39) | HRH4NPY5RACHE | |
| SCHEMBL4875369 | 0.72 | HRH4 (0.48) | HRH4NPY5REPHA4 | |
| SCHEMBL4588982 | 0.72 | HRH4 (0.57) | HRH4NPC1ADORA2AACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735411-B2 | Macrocyclic benzofused pyrimidine derivatives | ABBVIE INC. (US) | 2014-05-27 | — | — | US | disclosed |
| US-20080188452-A1 | Macrocyclic Benzofused Pyrimidine Derivatives | ABBVIE INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188452-A1 | Macrocyclic Benzofused Pyrimidine Derivatives | DPYD, TYMS, UMPS | HRH4 3013/4885NPC1 313/4885NPY5R 4096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.