Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Picotamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.91 |
| ▸ | TSHR | P16473 | 1/20 | 0.91 |
| ▸ | BLM | P54132 | 1/20 | 0.91 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.89 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Picotamide SCHEMBL4878567 | 0.98 | CYP1A2 (0.91) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL30254057 | 0.96 | CYP1A2 (1.00) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL137025 | 0.96 | CYP1A2 (1.00) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL30206880 | 0.96 | CYP1A2 (1.00) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL4877561 | 0.94 | CYP1A2 (0.98) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL4206054 | 0.94 | CYP1A2 (0.98) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL2916058 | 0.94 | L3MBTL1 (1.00) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL4875206 | 0.92 | CYP1A2 (0.93) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL4869999 | 0.92 | CYP1A2 (0.93) | CYP1A2CYP3A4TSHRBLML3MBTL1 | |
| Picotamide SCHEMBL4875152 | 0.91 | CYP1A2 (0.79) | CYP1A2CYP3A4TSHRBLML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293772-A1 | SALTS OF PICOTAMIDE | DYBLY AG (CH) | 2008-11-27 | — | — | US | claimed |
| WO-2008142106-A1 | SALTS OF PICOTAMIDE | DYBLY AG (CH) | 2008-11-27 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293772-A1 | SALTS OF PICOTAMIDE | SLC5A2, PHPT1, SLC5A1 | CYP1A2 1709/4885CYP3A4 971/4885TSHR 4640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.