Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | ESR1 | P03372 | 4/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.32 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196810 | 0.90 | TDP1 (0.75) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL11677444 | 0.90 | TDP1 (0.75) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL6388599 | 0.90 | TDP1 (0.75) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL11678746 | 0.90 | TDP1 (0.75) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL101 | 0.89 | TDP1 (1.00) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL2085135 | 0.89 | TDP1 (1.00) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Benzene SCHEMBL6890099 | 0.89 | TDP1 (1.00) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL5028587 | 0.89 | TDP1 (1.00) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Dibromodifluoromethane SCHEMBL15949801 | 0.88 | TDP1 (0.71) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL11728684 | 0.88 | TDP1 (0.71) | TDP1CYP3A4ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 580 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113278021-B | Preparation method of 1, 7-diazaspiro [3.5] nonane-7-tert-butyl formate and oxalate thereof | 天津全和诚科技有限责任公司 | 2022-09-23 | — | — | CN | claimed |
| CN-113278021-A | Preparation method of 1, 7-diazaspiro [3.5] nonane-7-tert-butyl formate and oxalate thereof | 天津全和诚科技有限责任公司 | 2021-08-20 | — | — | CN | claimed |
| CN-112694434-A | New lefenacin intermediate, active electrophilic building block thereof and new preparation method of lefenacin | 浙江和泽医药科技股份有限公司 | 2021-04-23 | — | — | CN | claimed |
| CN-106467521-A | Two kinds of preparation methoies of one class bisbenzimidazole indole derivativeses | 陈志龙 | 2017-03-01 | — | — | CN | claimed |
| CN-105111121-A | Selenium-containing alkyl tertiary amine compound and preparation method thereof | UNIV JIANGNAN | 2015-12-02 | — | — | CN | claimed |
| CN-101863792-B | Amide oligomer and polyamide paste rheological aid prepared by swelling same | CAS GUANGZHOU CHEMISTRY CO LTD | 2013-07-03 | — | — | CN | claimed |
| CN-101921229-B | Synthesis method of stepholidine or derivative optical isomer thereof and intermediate thereof | SHANGHAI INST MATERIA MEDICA | 2012-08-08 | — | — | CN | claimed |
| CN-101921229-A | Synthesis method of stepholidine or derivative optical isomer thereof and intermediate thereof | SHANGHAI INST MATERIA MEDICA | 2010-12-22 | — | — | CN | claimed |
| CN-101863792-A | Amide oligomer and polyamide paste rheological aid prepared by swelling same | GUANGZHOU CHEMISTRY CO LTD CAS | 2010-10-20 | — | — | CN | claimed |
| CN-1555351-A | Process for preparing unsaturated aliphatic hydroxy acids and esters thereof, use in pharmaceutical and/or cosmetic compositions | 皮埃尔・波捷 | 2004-12-15 | — | — | CN | claimed |
| EP-0137717-A2 | Fungicidal triazole and imidazole compounds | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-17 | — | — | EP | claimed |
| US-12227482-B2 | Compounds and compositions for the treatment of cancer | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-02-18 | — | — | US | disclosed |
| CN-116606239-B | Photo-induced CBr4Preparation method for constructing 3-bromo-spiro [4,5] triene ketone compound | 三峡大学 | 2024-10-18 | — | — | CN | disclosed |
| EP-4339192-A2 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | The Regents of the University of California (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2024022998-A1 | PROCESS FOR PREPARING DAPRODUSTAT AND COCRYSTALS THEREOF | INKE, S.A. (ES) | 2024-02-01 | — | — | WO | disclosed |
| EP-0109225-A1 | Arachidonic acid analogues, processes for their preparation and their use in medicine | BEECHAM GROUP PLC (GB) | 1984-05-23 | — | — | EP | disclosed |
| EP-0086611-A1 | 9-Substituted carbacyclin analogues | THE UPJOHN COMPANY (US) | 1983-08-24 | — | — | EP | disclosed |
| EP-0074599-A1 | 5,6-cis-Carbapenem derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-03-23 | — | — | EP | disclosed |
| US-4221717-A | Total synthesis of the utero-evacuant substance D,L-zoapatanol | ORTHO PHARMACEUTICAL CORPORATION (US) | 1980-09-09 | — | — | US | disclosed |
| US-4182717-A | Total synthesis of the utero-evacuant substance d,l-zoapatanol | ORTHO PHARMACEUTICAL CORP. (US) | 1980-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12227482-B2 | Compounds and compositions for the treatment of cancer | TP53, HCCS, CFTR | TDP1 2795/4885CYP3A4 2168/4885ESR1 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.