Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iothalamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iothalamic Acid SCHEMBL180546 | 1.00 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iothalamic Acid SCHEMBL29488709 | 1.00 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iothalamic Acid SCHEMBL3060866 | 0.99 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Diatrizoic Acid SCHEMBL720469 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL1685085 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL107036 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL2501947 | 0.91 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL468613 | 0.91 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Ioxitalamic Acid SCHEMBL29730019 | 0.89 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iocarmic Acid SCHEMBL29886627 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9918786-B2 | Spinal disk herniation repositioning and radiofrequency ablation (RFA) device and method for treating vertebral disc herniation | WANG HONGKUI (CN) | 2018-03-20 | — | — | US | disclosed |
| US-20150100052-A1 | SPINAL DISK HERNIATION REPOSITIONING AND RADIOFREQUENCY ABLATION (RFA) DEVICE AND METHOD FOR TREATING VERTEBRAL DISC HERNIATION | WANG JINSHENG (CN) | 2015-04-09 | — | — | US | disclosed |
| US-8226697-B2 | Method for treating intervertebral disc | NEUROTHERM, INC. (US) | 2012-07-24 | — | — | US | disclosed |
| US-8187312-B2 | Method for treating intervertebral disc | NEUROTHERM, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8128619-B2 | Method for treating intervertebral discs | NEUROTHERM, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-7896909-B2 | Method for treating intervertebral discs | NEUROTHERM, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20100022943-A1 | Hydrodynamic Thrombectomy Catheter | MEDTRONIC VASCULAR, INC. (US) | 2010-01-28 | — | — | US | disclosed |
| US-7647123-B2 | Method for treating intervertebral discs | ORATEC INTERVENTIONS, INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7632294-B2 | Devices and methods for spine repair | PROMETHEAN SURGICAL DEVICES, LLC (US) | 2009-12-15 | — | — | US | disclosed |
| US-7449019-B2 | Intervertebral decompression | SMITH & NEPHEW, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-6122549-A | Apparatus for treating intervertebral discs with resistive energy | ORATEC INTERVENTIONS, INC. (US) | 2000-09-19 | — | — | US | disclosed |
| US-6099514-A | Method and apparatus for delivering or removing material from the interior of an intervertebral disc | ORATEC INTERVENTIONS, INC. (US) | 2000-08-08 | — | — | US | disclosed |
| US-6095149-A | Method for treating intervertebral disc degeneration | ORATEC INTERVENTIONS, INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-1006885-A2 | METHOD AND APPARATUS FOR TREATING INTERVERTEBRAL DISCS | Oratec Interventions, Inc. (US) | 2000-06-14 | — | — | EP | disclosed |
| US-6073051-A | Apparatus for treating intervertebal discs with electromagnetic energy | ORATEC INTERVENTIONS, INC. | 2000-06-06 | — | — | US | disclosed |
| US-6007570-A | Apparatus with functional element for performing function upon intervertebral discs | ORATEC INTERVENTIONS, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5980504-A | Method for manipulating tissue of an intervertebral disc | ORATEC INTERVENTIONS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1999047058-A2 | CATHETER FOR DELIVERY OF ENERGY TO A SURGICAL SITE | ORATEC INTERVENTIONS, INC. (US) | 1999-09-23 | — | — | WO | disclosed |
| WO-1998017190-A9 | METHOD AND APPARATUS FOR TREATING INTERVERTEBRAL DISCS | — | 1999-01-21 | — | — | WO | disclosed |
| WO-1998017190-A2 | METHOD AND APPARATUS FOR TREATING INTERVERTEBRAL DISCS | ORATEC INTERVENTIONS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |