Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iothalamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iothalamic Acid SCHEMBL48785 | 1.00 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iothalamic Acid SCHEMBL29488709 | 1.00 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iothalamic Acid SCHEMBL3060866 | 0.99 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Diatrizoic Acid SCHEMBL720469 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL1685085 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL107036 | 0.92 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL2501947 | 0.91 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL468613 | 0.91 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Ioxitalamic Acid SCHEMBL29730019 | 0.89 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iocarmic Acid SCHEMBL29886627 | 0.88 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 989 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025124483-A1 | ORAL DRUG DOSAGE FORM FOR TARGETED DRUG DELIVERY BASED ON TRACKING MARKER AND METHODS OF DESIGN AND USE THEREOF | Triastek, Inc. (CN) | 2025-06-19 | — | — | WO | claimed |
| EP-4543498-A2 | COMPOSITION AND METHOD FOR DIAGNOSTIC IMAGING | Suntec Medical, Inc. (US) | 2025-04-30 | — | — | EP | claimed |
| US-20250121100-A1 | COMPOSITION AND METHOD FOR DIAGNOSTIC IMAGING | SUNTEC MEDICAL INC (US) | 2025-04-17 | — | — | US | claimed |
| CN-119698306-A | Compositions and methods for diagnostic imaging | 欣扬生医股份有限公司 | 2025-03-25 | — | — | CN | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| WO-2023250377-A2 | COMPOSITION AND METHOD FOR DIAGNOSTIC IMAGING | SUNTEC MEDICAL, INC. (US) | 2023-12-28 | — | — | WO | claimed |
| CN-210249862-U | Earplug for external auditory canal CT scanning and positioning | 中国人民解放军总医院第八医学中心 | 2020-04-07 | — | — | CN | claimed |
| US-10245446-B2 | Marker-flange for MRI-guided brachytherapy | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2019-04-02 | — | — | US | claimed |
| EP-3234000-A1 | CHITOSAN-BASED HYDROGEL AND APPLICATIONS THEREOF | Socovar, L.P. (CA) | 2017-10-25 | — | — | EP | claimed |
| CN-107115534-A | A kind of intestines and stomach diagnostic imaging imaging assistant and preparation method thereof | 山东赛克赛斯生物科技有限公司 | 2017-09-01 | — | — | CN | claimed |
| US-5989198-A | Use of capillary electrophoresis to determine glomerular filtration rate using iothalamate | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 1999-11-23 | — | — | US | claimed |
| EP-0752894-B1 | PRE-FILLED SYRINGE WITH LUGS | NYCOMED IMAGING AS (NO) | 1998-12-30 | — | — | EP | claimed |
| EP-0752894-A1 | PRE-FILLED SYRINGE WITH LUGS | NYCOMED IMAGING AS (NO) | 1997-01-15 | — | — | EP | claimed |
| EP-0752832-A1 | MEASUREMENT OF NUCLEOUS MATERIALS REMOVED DURING DISCECTOMY | HOWMEDICA INC. (US) | 1997-01-15 | — | — | EP | claimed |
| US-5535746-A | Prefilled syringe for use with power injector | STERLING WINTHROP INC. (US) | 1996-07-16 | — | — | US | claimed |
| EP-0684786-A1 | FIDUCIAL MARKER | McCrory, Jennifer J. (US) | 1995-12-06 | — | — | EP | claimed |
| WO-1995026689-A1 | MEASUREMENT OF NUCLEOUS MATERIALS REMOVED DURING DISCECTOMY | HOWMEDICA INC. (US) | 1995-10-12 | — | — | WO | claimed |
| WO-1995026211-A1 | PRE-FILLED SYRINGE WITH LUGS | NYCOMED IMAGING AS (NO) | 1995-10-05 | — | — | WO | claimed |
| US-5377681-A | In an organ of a patient | UNIVERSITY OF FLORIDA (US) | 1995-01-03 | — | — | US | claimed |
| WO-1994017733-A1 | FIDUCIAL MARKER | MCCRORY, JENNIFER, J. (US) | 1994-08-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250121100-A1 | COMPOSITION AND METHOD FOR DIAGNOSTIC IMAGING | ABCB4, C5, APOB | SMN1; SMN2 2359/4885LMNA 793/4885KDM4E 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.