Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | HRH2 | P25021 | 1/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4540946 | 0.99 | TLR7 (0.67) | TLR7PDE4DLMNAPOLBHRH2 | |
| Glycine SCHEMBL3195843 | 0.94 | TLR7 (0.61) | TLR7PDE4DLMNAPOLBHRH2 | |
| Sarcosine SCHEMBL18477799 | 0.93 | TLR7 (0.59) | TLR7PDE4DLMNAPOLBHRH2 | |
| SCHEMBL18477815 | 0.93 | TLR7 (0.59) | TLR7PDE4DLMNAPOLBHRH2 | |
| Sarcosine SCHEMBL3191326 | 0.92 | TLR7 (0.58) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL5262205 | 0.83 | TLR7 (0.88) | TLR7PDE4DLMNAPOLBHRH2 | |
| SCHEMBL3176637 | 0.83 | TLR7 (0.46) | TLR7PDE4DLMNAPOLBHRH2 | |
| Hydrochloric Acid SCHEMBL3195855 | 0.83 | TLR7 (0.58) | TLR7PDE4DLMNAPOLBHRH2 | |
| SCHEMBL3192280 | 0.82 | TLR7 (0.46) | TLR7PDE4DLMNAPOLBHRH2 | |
| Hydrochloric Acid SCHEMBL18916713 | 0.82 | TLR7 (0.46) | TLR7PDE4DLMNAPOLBHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106202-B2 | Method for making 1-substituted 1H-imidazo [4,5-C] quinolin-4-amine compounds and intermediates therefor | FERRER INTERNACIONAL, S.A. (ES) | 2012-01-31 | — | — | US | claimed |
| EP-1879893-B1 | METHOD FOR MAKING 1-SUBSTITUTED 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE COMPOUNDS AND INTERMEDIATES THEREFOR | FERRER INT (ES) | 2010-06-02 | — | — | EP | claimed |
| US-20090005566-A1 | Method for Making 1-Substituted 1H-Imidazo [4,5-C] Quinolin-4-Amine Compounds and Intermediates Therefor | FERRER INTERNACIONAL, S.A. (ES) | 2009-01-01 | — | — | US | claimed |
| EP-3176169-A1 | POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND RELATED COMPOUNDS WITH VERY HIGH SKIN PENETRATION RATES | Yu, Chongxi (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9567329-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-c]quinolin-4-amines and 1H-imidazo[4,5-c]quinolin-4-amine-related compounds and uses thereof | TECHFIELDS PHARMA CO., LTD. (CN) | 2017-02-14 | — | — | US | disclosed |
| EP-2115140-B1 | Positively charged water-soluble prodrugs of 1H-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates | YU CHONGXI (US) | 2016-11-30 | — | — | EP | disclosed |
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-05-23 | — | — | US | disclosed |
| US-8349866-B2 | High penetration prodrug compositions of 1H-imidazo[4,5-C]quinolin-4-amines and 1H-imidazo[4,5-C]quinolin-4-amine-related compounds | PREMIER RESEARCH INTERNATIONAL, LLC | 2013-01-08 | — | — | US | disclosed |
| US-8106202-B2 | Method for making 1-substituted 1H-imidazo [4,5-C] quinolin-4-amine compounds and intermediates therefor | FERRER INTERNACIONAL, S.A. (ES) | 2012-01-31 | — | — | US | disclosed |
| EP-1879893-B1 | METHOD FOR MAKING 1-SUBSTITUTED 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE COMPOUNDS AND INTERMEDIATES THEREFOR | FERRER INT (ES) | 2010-06-02 | — | — | EP | disclosed |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | PREMIER RESEARCH INTERNATIONAL, LLC | 2010-01-28 | — | — | US | disclosed |
| US-20050119294-A1 | Preparation of 1H-imidazo [4,5-c] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | BIOGAL GYOGYSZERGYAR RT. | 2005-06-02 | — | — | US | disclosed |
| US-20050101627-A1 | Preparation of 1H-imidazo [4,5-C] quinolin-4 amines via novel 1h-imidazo [4,5-C] quinolin-4-cyano and 1h-imidazo [4,5-C] quinolin-4-carboxamide intermediates | TEVA PHARAMCEUTICAL INDUSTRIES LTD TO BIOGAL GYOGYSZERGYAR RT. | 2005-05-12 | — | — | US | disclosed |
| US-20050101627-A1 | Preparation of 1H-imidazo [4,5-C] quinolin-4 amines via novel 1h-imidazo [4,5-C] quinolin-4-cyano and 1h-imidazo [4,5-C] quinolin-4-carboxamide intermediates | TEVA PHARAMCEUTICAL INDUSTRIES LTD TO BIOGAL GYOGYSZERGYAR RT. | 2005-05-12 | — | — | US | disclosed |
| US-6841678-B2 | Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | BIOGAL GYOGYSZERGYAR RT. (HU) | 2005-01-11 | — | — | US | disclosed |
| US-6841678-B2 | Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | BIOGAL GYOGYSZERGYAR RT. (HU) | 2005-01-11 | — | — | US | disclosed |
| US-20040063743-A1 | Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG (HU) | 2004-04-01 | — | — | US | disclosed |
| US-20040063743-A1 | Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG (HU) | 2004-04-01 | — | — | US | disclosed |
| WO-2004011462-A1 | PREPARATION OF 1H-IMIDAZO [4,5-C] QUINOLIN-4-AMINES VIA NOVEL 1H-IMIDAZO [4,5-C] QUINOLIN-4-CYANO AND 1H-IMIDAZO [4,5-C] QUINOLIN-4-CARBOXAMIDE INTERMEDIATES | BIOGAL GYOGYSZERGYAR RT. (HU) | 2004-02-05 | — | — | WO | disclosed |
| WO-2004011462-A1 | PREPARATION OF 1H-IMIDAZO [4,5-C] QUINOLIN-4-AMINES VIA NOVEL 1H-IMIDAZO [4,5-C] QUINOLIN-4-CYANO AND 1H-IMIDAZO [4,5-C] QUINOLIN-4-CARBOXAMIDE INTERMEDIATES | BIOGAL GYOGYSZERGYAR RT. (HU) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101627-A1 | Preparation of 1H-imidazo [4,5-C] quinolin-4 amines via novel 1h-imidazo [4,5-C] quinolin-4-cyano and 1h-imidazo [4,5-C] quinolin-4-carboxamide intermediates | KDM4C, P2RX4, IL4 | TLR7 4/4885PDE4D 578/4885LMNA 430/4885 |
| US-20130131100-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS AND USES THEREOF | HRH4, SLC7A1, ABCG2 | TLR7 1432/4885PDE4D 747/4885LMNA 1869/4885 |
| US-20100021394-A1 | HIGH PENETRATION PRODRUG COMPOSITIONS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINES AND 1H-IMIDAZO[4,5-C]QUINOLIN-4-AMINE-RELATED COMPOUNDS | SLC7A1, HRH4, CYP3A4 | TLR7 1413/4885PDE4D 797/4885LMNA 1935/4885 |
| US-20040063743-A1 | Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | IL4, MCM4, CUL4A | TLR7 13/4885PDE4D 498/4885LMNA 632/4885 |
| US-20050119294-A1 | Preparation of 1H-imidazo [4,5-c] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates | KDM4C, IFNAR1, P2RX4 | TLR7 8/4885PDE4D 559/4885LMNA 539/4885 |
| US-20090005566-A1 | Method for Making 1-Substituted 1H-Imidazo [4,5-C] Quinolin-4-Amine Compounds and Intermediates Therefor | CYP4B1, QARS1, CYP4F11 | TLR7 1849/4885PDE4D 671/4885LMNA 2306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.