Sugi Predict

Sugi Predict / Compounds / SCHEMBL4879211

SCHEMBL4879211

SCHEMBL4879211

O=C(Nc1ccc(C2[C@@H](CO)[C@H]2CO)c(F)c1)OCc1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 3/20 0.55
▸ ENPP2 Q13822 3/20 0.50
▸ TP53 P04637 2/20 0.50
▸ MAPT P10636 2/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ ALDH1A1 P00352 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ ATM Q13315 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ POLB P06746 1/20 0.48
▸ KDM1A O60341 3/20 0.47
▸ MAOA P21397 3/20 0.47
▸ MAOB P27338 2/20 0.47
▸ ROCK2 O75116 1/20 0.47
▸ RCOR1 Q9UKL0 2/20 0.46
▸ PTGDR2 Q9Y5Y4 1/20 0.46
▸ KDM1B Q8NB78 1/20 0.45
▸ PTPN1 P18031 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14197104 1.00 MGLL (0.55) MGLLENPP2TP53MAPTNPC1
SCHEMBL5378627 0.86 MGLL (0.51) MGLLENPP2TP53MAPTNPC1
SCHEMBL14370631 0.86 MGLL (0.51) MGLLENPP2TP53MAPTNPC1
SCHEMBL14197105 0.84 MGLL (0.48) MGLLENPP2TP53MAPTNPC1
SCHEMBL4874563 0.84 MGLL (0.48) MGLLENPP2TP53MAPTNPC1
SCHEMBL4882624 0.83 TP53 (0.53) MGLLENPP2TP53MAPTNPC1
SCHEMBL14197109 0.83 MGLL (0.52) MGLLENPP2TP53MAPTNPC1
SCHEMBL4875448 0.83 MGLL (0.52) MGLLENPP2TP53MAPTNPC1
SCHEMBL4879529 0.83 MGLL (0.52) MGLLENPP2TP53MAPTNPC1
SCHEMBL14197111 0.83 TP53 (0.53) MGLLENPP2TP53MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090884-A1 ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL- OXAZOLIDINONE DERIVATIVES AND ANALOGUES PFIZER INC 2008-04-17 — — US disclosed
US-7279494-B2 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues PFIZER INC. (US) 2007-10-09 — — US disclosed
EP-1615916-A1 ANTIMICROBIAL 3.1.0 BICYCLOHEXYLPHENYL-OXAZOLIDINONE DERIVATIVES AND ANALOGUES Pharmacia & Upjohn Company LLC (US) 2006-01-18 — — EP disclosed
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues RENSLO ADAM (US) 2005-09-01 — — US disclosed
WO-2004089943-A1 ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL-OXAZOLIDINONE DERIVATIVES AND ANALOGUES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-10-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050192325-A1 Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues OXA1L, CYP51A1, CYP2C19 MGLL 1507/4885ENPP2 4605/4885TP53 4646/4885
US-20080090884-A1 ANTIMICROBIAL [3.1.0] BICYCLOHEXYLPHENYL- OXAZOLIDINONE DERIVATIVES AND ANALOGUES OXA1L, CYP51A1, CYP2C19 MGLL 1527/4885ENPP2 4618/4885TP53 4608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.