Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.56 |
| ▸ | INSR | P06213 | 12/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.46 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1887284 | 0.92 | IGF1R (0.56) | IGF1RINSRALKMETAXL | |
| SCHEMBL1886572 | 0.91 | IGF1R (0.56) | IGF1RINSRALKMETAXL | |
| SCHEMBL1888022 | 0.90 | IGF1R (0.58) | IGF1RINSRALKMETAXL | |
| SCHEMBL1885697 | 0.90 | IGF1R (0.62) | IGF1RINSRALKMETAXL | |
| SCHEMBL1893859 | 0.89 | IGF1R (0.52) | IGF1RINSRALKMETAXL | |
| SCHEMBL1892565 | 0.89 | IGF1R (0.55) | IGF1RINSRALKMETAXL | |
| SCHEMBL1895223 | 0.89 | IGF1R (0.55) | IGF1RINSRALKMETAXL | |
| SCHEMBL1889323 | 0.89 | IGF1R (0.55) | IGF1RINSRALKMETAXL | |
| SCHEMBL1888291 | 0.88 | INSR (0.61) | IGF1RINSRALKMETAXL | |
| SCHEMBL1884807 | 0.88 | IGF1R (0.56) | IGF1RINSRALKMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |