Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.48 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 7/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4879687 | 1.00 | L3MBTL3 (0.48) | L3MBTL3TMPRSS2NAMPTACHEHSD17B3 | |
| SCHEMBL4775592 | 0.87 | HDAC8 (0.49) | L3MBTL3TMPRSS2NAMPTACHEHSD17B3 | |
| SCHEMBL4909738 | 0.87 | HDAC8 (0.49) | L3MBTL3TMPRSS2NAMPTACHEHSD17B3 | |
| SCHEMBL4795400 | 0.70 | HSD17B3 (0.67) | L3MBTL3TMPRSS2NAMPTACHEHSD17B3 | |
| SCHEMBL4792576 | 0.69 | HDAC8 (0.76) | TMPRSS2ACHEHDAC8 | |
| SCHEMBL4794126 | 0.69 | HDAC8 (0.76) | TMPRSS2ACHEHDAC8 | |
| SCHEMBL4882090 | 0.69 | HDAC8 (0.60) | TMPRSS2NAMPTACHENPC1RAB9A | |
| SCHEMBL4882084 | 0.69 | HDAC8 (0.60) | TMPRSS2NAMPTACHENPC1RAB9A | |
| SCHEMBL22493880 | 0.68 | TMPRSS2 (0.57) | L3MBTL3TMPRSS2NAMPTACHEHSD17B3 | |
| SCHEMBL4779013 | 0.68 | HDAC8 (0.60) | NPC1RAB9AHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | disclosed |