Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.66 |
| ▸ | ATR | Q13535 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 3/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | YES1 | P07947 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3755477 | 0.96 | NOS1 (0.68) | NOS1ATRPIK3CGPIK3CAPIK3CB | |
| SCHEMBL3755510 | 0.93 | NOS1 (0.70) | NOS1ATRPIK3CGPIK3CAADK | |
| SCHEMBL4880291 | 0.90 | NOS1 (0.51) | NOS1ATRPIK3CGPIK3CAADK | |
| SCHEMBL3765571 | 0.83 | NOS1 (0.67) | NOS1ATRPIK3CGPIK3CAMAPK1 | |
| SCHEMBL3755627 | 0.82 | NOS1 (0.72) | NOS1ATRPIK3CGPIK3CAPIK3CB | |
| SCHEMBL4451911 | 0.81 | NOS1 (0.79) | NOS1ATRPIK3CGPIK3CAPIK3CB | |
| SCHEMBL3762228 | 0.81 | NOS1 (0.95) | NOS1ATRPIK3CGPIK3CAADK | |
| SCHEMBL4448697 | 0.81 | NOS1 (0.63) | NOS1ATRPIK3CGPIK3CAMAPK1 | |
| SCHEMBL5317835 | 0.81 | NOS1 (1.00) | NOS1PIK3CGPIK3CAADKMAPK1 | |
| SCHEMBL3768161 | 0.80 | NOS1 (0.74) | NOS1ATRPIK3CGPIK3CAADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009079-A2 | SUBSTITUTED PTERIDINES USEFUL FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |