Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 10/20 | 0.35 |
| ▸ | LITAF | Q99732 | 10/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880839 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PDE4BPDE4DMELKPDE4A | |
| SCHEMBL871894 | 0.89 | MELK (0.37) | ALDH1A1PDE4BPDE4DMELKTNF | |
| SCHEMBL871893 | 0.89 | MELK (0.37) | ALDH1A1PDE4BPDE4DMELKTNF | |
| SCHEMBL4879121 | 0.89 | TTK (0.39) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4879107 | 0.89 | TTK (0.39) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4886115 | 0.89 | PDE4B (0.39) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4886119 | 0.89 | PDE4B (0.39) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4883220 | 0.88 | TTK (0.40) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4883226 | 0.88 | TTK (0.40) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4875799 | 0.88 | TTK (0.40) | ALDH1A1PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | US | claimed |
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | ASTRAZENECA AB (SE) | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227797-A1 | Pyridopyrimidine Derivatives as Pde4 Inhibitors for the Treatment of Inflammatory and Immune Diseases | PDE4A, PDE4B, PDE5A | ALDH1A1 809/4885PDE4B 2/4885PDE4D 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.