Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.61 |
| ▸ | CCND1 | P24385 | 18/20 | 0.61 |
| ▸ | CCND2 | P30279 | 12/20 | 0.61 |
| ▸ | CCND3 | P30281 | 12/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 13/20 | 0.61 |
| ▸ | CDK2 | P24941 | 13/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.61 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.61 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.61 |
| ▸ | CDK1 | P06493 | 3/20 | 0.61 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.61 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.58 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190547 | 0.90 | CDK4 (0.61) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL4218283 | 0.84 | CDK4 (0.54) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL4220885 | 0.83 | CDK4 (0.53) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL14300938 | 0.79 | PIK3CD (0.58) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL4226220 | 0.78 | PIK3CA (0.49) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL4676481 | 0.76 | CDK4 (0.74) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL6941108 | 0.76 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL190132 | 0.76 | CDK4 (0.62) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL4218445 | 0.76 | PIK3CA (0.51) | CDK4CCND1CCND2CCND3CCNA2 | |
| SCHEMBL14301297 | 0.75 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931670-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3K | Exelixis, Inc. (US) | 2008-06-18 | — | — | EP | claimed |
| WO-2007044698-A1 | PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | claimed |