Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 5/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621360 | 0.94 | MEN1 (0.41) | MAPK8CA2MEN1NPC1LMNA | |
| Trifluoroacetic Acid SCHEMBL4884964 | 0.91 | PTK2 (0.39) | PTK2MAPK8CA2MEN1NPC1 | |
| Trifluoroacetic Acid SCHEMBL4876720 | 0.91 | PTK2 (0.39) | PTK2MAPK8MEN1NPC1LMNA | |
| Trifluoroacetic Acid SCHEMBL4881253 | 0.88 | MAPK8 (0.41) | PTK2MAPK8MEN1NPC1LMNA | |
| Trifluoroacetic Acid SCHEMBL4884485 | 0.88 | NAMPT (0.46) | MAPK8CA2ACVR1 | |
| Trifluoroacetic Acid SCHEMBL4883185 | 0.87 | NAMPT (0.46) | MAPK8CA2MEN1NPC1LMNA | |
| Trifluoroacetic Acid SCHEMBL4881263 | 0.86 | MAPK8 (0.38) | PTK2MAPK8MEN1NPC1LMNA | |
| Trifluoroacetic Acid SCHEMBL4876640 | 0.86 | MAPK8 (0.36) | PTK2MAPK8CA2MEN1NPC1 | |
| Trifluoroacetic Acid SCHEMBL4881433 | 0.86 | L3MBTL1 (0.35) | PTK2MAPK8CA2MEN1NPC1 | |
| Trifluoroacetic Acid SCHEMBL4877560 | 0.86 | MAPK8 (0.39) | PTK2MAPK8MEN1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269170-A1 | Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors | SANOFI-AVENTIS (FR) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269170-A1 | Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors | NFKBIA, IKBKB, IKBKE | PTK2 479/4885MAPK8 290/4885CA2 3293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.