Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.61 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264288 | 0.98 | IRAK4 (0.63) | IRAK4CTSDCTNNB1HTTCA12 | |
| SCHEMBL29423358 | 0.98 | IRAK4 (0.63) | IRAK4CTSDCTNNB1HTTCA12 | |
| Hydrochloric Acid SCHEMBL408014 | 0.96 | IRAK4 (0.61) | IRAK4CTSDCTNNB1HTTCA12 | |
| SCHEMBL31174577 | 0.96 | IRAK4 (0.61) | IRAK4CTSDCTNNB1HTTCA12 | |
| SCHEMBL31174576 | 0.96 | IRAK4 (0.61) | IRAK4CTSDCTNNB1HTTCA12 | |
| Hydrochloric Acid SCHEMBL3144924 | 0.96 | IRAK4 (0.61) | IRAK4CTSDCTNNB1HTTCA12 | |
| Hydrochloric Acid SCHEMBL4374712 | 0.96 | IRAK4 (0.61) | IRAK4CTSDCTNNB1HTTCA12 | |
| Water SCHEMBL27147733 | 0.96 | IRAK4 (0.61) | IRAK4CTSDCTNNB1HTTCA12 | |
| Hydrochloric Acid SCHEMBL5151052 | 0.94 | IRAK4 (0.59) | IRAK4CTSDCTNNB1HTTCA12 | |
| Formaldehyde SCHEMBL28111271 | 0.94 | IRAK4 (0.59) | IRAK4CTSDCTNNB1HTTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153854-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | US | disclosed |
| US-20060270689-A1 | Novel Fused Heterocycles and Uses Thereof | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | US | disclosed |
| US-20060063751-A1 | Novel fused heterocycles and uses thereof | ASTRAZENECA AB (SE) | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063751-A1 | Novel fused heterocycles and uses thereof | RB1, CDK19, PRMT9 | IRAK4 2089/4885CTSD 3430/4885CTNNB1 2594/4885 |
| US-20080153854-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | RB1, CDK19, PRMT9 | IRAK4 2089/4885CTSD 3430/4885CTNNB1 2594/4885 |
| US-20060270689-A1 | Novel Fused Heterocycles and Uses Thereof | BRCA1, CYP1B1, CCNI | IRAK4 2225/4885CTSD 3585/4885CTNNB1 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.