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PRMT9

Protein arginine N-methyltransferase 9 · Q6P2P2 · PRMT9 on Sugi Atlas →

74 patent compounds predicted against PRMT9, 45 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL19540106 SCHEMBL19540106 0.59 7/20
SCHEMBL9938332 SCHEMBL9938332 0.60 4/20
SCHEMBL9938337 SCHEMBL9938337 0.60 4/20
SCHEMBL643567 SCHEMBL643567 0.60 1/20
SCHEMBL25168483 SCHEMBL25168483 0.53 1/20
SCHEMBL646028 SCHEMBL646028 0.52 1/20
SCHEMBL23324021 SCHEMBL23324021 0.48 1/20
SCHEMBL4869572 SCHEMBL4869572 0.48 1/20
SCHEMBL9970643 SCHEMBL9970643 0.47 1/20
SCHEMBL4862163 SCHEMBL4862163 0.47 1/20
SCHEMBL4862183 SCHEMBL4862183 0.47 1/20
SCHEMBL4862230 SCHEMBL4862230 0.47 1/20
SCHEMBL4863149 SCHEMBL4863149 0.47 1/20
SCHEMBL4867397 SCHEMBL4867397 0.47 1/20
SCHEMBL4867938 SCHEMBL4867938 0.47 1/20
SCHEMBL4867945 SCHEMBL4867945 0.47 1/20
SCHEMBL4867962 SCHEMBL4867962 0.47 1/20
SCHEMBL14279857 SCHEMBL14279857 0.47 1/20
SCHEMBL14279867 SCHEMBL14279867 0.47 1/20
SCHEMBL4868234 SCHEMBL4868234 0.46 1/20

Clinical trials — most relevant to PRMT9 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial PHASE3COMPLETED
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study) PHASE3RECRUITING
L-Arginine in Pre-Eclampsia PHASE3COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors PHASE1/PHASE2RECRUITING
Effect of Arginine- and Glutamine-based Oral Formulations on Salivary Biomarkers and Clinical Severity of Radiation-induced Oral Mucositis in Head and Neck Cancer: A Randomized Controlled Trial PHASE2COMPLETED
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma PHASE2SUSPENDED
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors PHASE1RECRUITING
Arginase-1 Peptide Vaccine in Patients With Metastatic Solid Tumors PHASE1COMPLETED
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors PHASE1COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors PHASE1RECRUITING
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. EARLY_PHASE1COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD nanUNKNOWN
The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart Failure nanENROLLING_BY_INVITATION
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment nanUNKNOWN
Patient's Derived Organoids for Drug Screening in Glioblastoma nanNOT_YET_RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia nanUNKNOWN
Effect of L-Citrulline Supplementation on Arginase Activity and Vascular Function in Diabetes nanUNKNOWN
Study of the Articular Microbiota in Rheumatoid Arthritis. nanCOMPLETED
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD nanCOMPLETED
DNA Methylation and Perioperative Pain Treatment nanCOMPLETED
Studying The Role of Key Epigenetic Mediators in Breast Cancer Patients nanRECRUITING
A Study of Multilocus Methylation Abnormalities in Subjects With Imprinting Disorders nanNOT_YET_RECRUITING
Preterm Arginine INTake Study nanCOMPLETED
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) nanRECRUITING
HIIT and MICT on Nitric Oxide-mediated Erythrocyte Rheology nanUNKNOWN
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PRMT9 binder may also engage these)

ProteinNameSimilarity
Q3U3W5 — 1.000 Q3U3W5 →
A0JMU5 — 0.997 A0JMU5 →
Q5ZIB9 — 0.990 Q5ZIB9 →
Q5VS72 — 0.989 Q5VS72 →
Q944R7 — 0.988 Q944R7 →
Q80VJ4 — 0.988 Q80VJ4 →
Q5R5T0 — 0.988 Q5R5T0 →
D9IVE5 — 0.988 D9IVE5 →
A2Y8B9 — 0.987 A2Y8B9 →
Q6PCI6 — 0.987 Q6PCI6 →
A2AV36 — 0.987 A2AV36 →
Q8C0L9 — 0.987 Q8C0L9 →
Q10HL3 — 0.987 Q10HL3 →
Q4R6C7 — 0.987 Q4R6C7 →
O94952 — 0.986 O94952 →
P0CI65 — 0.986 P0CI65 →
A2RSY6 — 0.985 A2RSY6 →
B3DLB3 — 0.985 B3DLB3 →
Q4KLT3 — 0.985 Q4KLT3 →
Q69LX2 — 0.985 Q69LX2 →
Q8VD46 — 0.985 Q8VD46 →
TRMT1L tRNA (guanine(27)-N(2))-dimethyltransferase 0.985 landscape →
Q2QLA4 — 0.984 Q2QLA4 →
A5D7S3 — 0.984 A5D7S3 →
Q09YN0 — 0.984 Q09YN0 →
Q6DDT5 — 0.984 Q6DDT5 →
Q0P564 — 0.984 Q0P564 →
A0JM23 — 0.984 A0JM23 →
Q6AZT7 — 0.983 Q6AZT7 →
Q6PJI9 — 0.983 Q6PJI9 →