Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.67 |
| ▸ | CCR1 | P32246 | 2/20 | 0.67 |
| ▸ | CCR5 | P51681 | 2/20 | 0.67 |
| ▸ | CCR8 | P51685 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | METAP1 | P53582 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.67 |
| ▸ | KDM4A | O75164 | 2/20 | 0.60 |
| ▸ | KDM6B | O15054 | 1/20 | 0.60 |
| ▸ | KDM5C | P41229 | 1/20 | 0.60 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.60 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.60 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipyridyl SCHEMBL9641711 | 1.00 | KDM4E (0.67) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL11231947 | 1.00 | KDM4E (0.67) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL28330019 | 0.98 | KDM4E (0.64) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL3777739 | 0.98 | KDM4E (0.64) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL8773554 | 0.98 | KDM4E (0.64) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL2650926 | 0.98 | KDM4E (0.64) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL2792069 | 0.90 | KDM4E (0.74) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL18601618 | 0.90 | KDM4E (0.74) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL30976994 | 0.90 | KDM4E (0.74) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL7773433 | 0.90 | KDM4E (0.74) | KDM4ELMNAP4HTMCCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9024077-B2 | Fluorine-containing vinyl ether compound and method for producing the same | UNIMATEC CO., LTD. (JP) | 2015-05-05 | — | — | US | claimed |
| EP-2617700-B1 | NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR | UNIMATEC CO LTD (JP) | 2014-10-29 | — | — | EP | claimed |
| EP-2617700-A1 | NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR | Unimatec Co., Ltd. (JP) | 2013-07-24 | — | — | EP | claimed |
| US-20130178659-A1 | NOVEL FLUORINE-CONTAINING VINYL ETHER COMPOUND AND METHOD FOR PRODUCING THE SAME | UNIMATEC CO., LTD. (JP) | 2013-07-11 | — | — | US | claimed |
| US-20080090977-A1 | Fluorine-Containing Vinyl Ether Compound And Process For Producing The Same | UNIMATEC CO., LTD. (JP) | 2008-04-17 | — | — | US | claimed |
| EP-1760063-A1 | FLUORINE-CONTAINING VINYL ETHER COMPOUND AND PROCESS FOR PRODUCING THE SAME | Unimatec Co., Ltd. (JP) | 2007-03-07 | — | — | EP | claimed |
| US-9024077-B2 | Fluorine-containing vinyl ether compound and method for producing the same | UNIMATEC CO., LTD. (JP) | 2015-05-05 | — | — | US | disclosed |
| EP-2617700-B1 | NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR | UNIMATEC CO LTD (JP) | 2014-10-29 | — | — | EP | disclosed |
| EP-2617700-A1 | NOVEL FLUORINATED VINYL ETHER COMPOUND AND MANUFACTURING METHOD THEREFOR | Unimatec Co., Ltd. (JP) | 2013-07-24 | — | — | EP | disclosed |
| US-20130178659-A1 | NOVEL FLUORINE-CONTAINING VINYL ETHER COMPOUND AND METHOD FOR PRODUCING THE SAME | UNIMATEC CO., LTD. (JP) | 2013-07-11 | — | — | US | disclosed |
| US-20080090977-A1 | Fluorine-Containing Vinyl Ether Compound And Process For Producing The Same | UNIMATEC CO., LTD. (JP) | 2008-04-17 | — | — | US | disclosed |
| EP-1760063-A1 | FLUORINE-CONTAINING VINYL ETHER COMPOUND AND PROCESS FOR PRODUCING THE SAME | Unimatec Co., Ltd. (JP) | 2007-03-07 | — | — | EP | disclosed |
| US-4581178-A | USING TRANSITION METAL COMPLEXES CONTAINING PHOSPHINE OR ARSINE LI | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-04-08 | — | — | US | disclosed |