Dipyridyl

Dipyridyl

SCHEMBL8773554

CC(=O)O.[Pd].c1ccc(-c2ccccn2)nc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Dipyridyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.64
LMNA P02545 4/20 0.64
P4HTM Q9NXG6 3/20 0.64
CCR1 P32246 2/20 0.64
CCR5 P51681 2/20 0.64
CCR8 P51685 2/20 0.64
CYP1A2 P05177 1/20 0.64
POLB P06746 1/20 0.64
METAP1 P53582 1/20 0.64
BLM P54132 1/20 0.64
HIF1A Q16665 1/20 0.64
DOHH Q9BU89 1/20 0.64
KDM4A O75164 2/20 0.58
KDM6B O15054 1/20 0.58
KDM5C P41229 1/20 0.58
KDM4C Q9H3R0 1/20 0.58
KDM2A Q9Y2K7 1/20 0.58
KDM3A Q9Y4C1 1/20 0.58
ALDH1A1 P00352 5/20 0.54
L3MBTL1 Q9Y468 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dipyridyl SCHEMBL9641711 0.98 KDM4E (0.67) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL11231947 0.98 KDM4E (0.67) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL4881410 0.98 KDM4E (0.67) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL28330019 0.95 KDM4E (0.64) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL3777739 0.95 KDM4E (0.64) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL2650926 0.95 KDM4E (0.64) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL18601618 0.88 KDM4E (0.74) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL30976994 0.88 KDM4E (0.74) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL2792069 0.88 KDM4E (0.74) KDM4ELMNAP4HTMCCR1CCR5
Dipyridyl SCHEMBL7773433 0.88 KDM4E (0.74) KDM4ELMNAP4HTMCCR1CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11021499-B2 Bis(6-methyl-3-sulphophenyl)(2-methylphenyl)phosphine, ammonium salt thereof, and method for producing same KURARAY CO., LTD. (JP) 2021-06-01 US disclosed
US-10696701-B2 Bis(6-methyl-3-sulphophenyl)phenylphosphine, ammonium salt thereof, and method for producing same KURARAY CO., LTD. (JP) 2020-06-30 US disclosed
US-20190071460-A1 BIS(6-METHYL-3-SULPHOPHENYL)(2-METHYLPHENYL)PHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME HONDA ERIKO (JP) 2019-03-07 US disclosed
EP-2980093-B1 BIS(6-METHYL-3-SULPHOPHENYL)(2-METHYLPHENYL)PHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME KURARAY CO (JP) 2019-01-09 EP disclosed
US-20180141967-A1 BIS(6-METHYL-3-SULPHOPHENYL)PHENYLPHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME KURARAY CO., LTD. (JP) 2018-05-24 US disclosed
EP-2980055-B1 METHOD FOR PRODUCING 2,7-OCTADIEN-1-OL KURARAY CO (JP) 2017-11-15 EP disclosed
EP-2980092-B1 BIS(6-METHYL-3-SULPHOPHENYL)PHENYLPHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME KURARAY CO (JP) 2017-10-04 EP disclosed
US-9315433-B2 Method for producing 2,7-octadien-1-OL KURARAY CO., LTD. (JP) 2016-04-19 US disclosed
US-20160052948-A1 BIS(6-METHYL-3-SULPHOPHENYL)(2-METHYLPHENYL)PHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME KURARAY CO., LTD. (JP) 2016-02-25 US disclosed
US-20160052947-A1 BIS(6-METHYL-3-SULPHOPHENYL)PHENYLPHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME KURARAY CO., LTD. (JP) 2016-02-25 US disclosed
EP-2980092-A1 BIS(6-METHYL-3-SULPHOPHENYL)PHENYLPHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME Kuraray Co., Ltd. (JP) 2016-02-03 EP disclosed
EP-2980093-A1 BIS(6-METHYL-3-SULPHOPHENYL)(2-METHYLPHENYL)PHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME Kuraray Co., Ltd. (JP) 2016-02-03 EP disclosed
EP-2980055-A1 METHOD FOR PRODUCING 2,7-OCTADIEN-1-OL Kuraray Co., Ltd. (JP) 2016-02-03 EP disclosed
US-5696304-A REACTING CONJUGATED ALKADIENOL WITH WATER USING PALLADIUM CATALYST IN LOW BOILING REACTION SOLVENT, THEN DISTILLATION MITSUBISHI CHEMICAL CORPORATION (JP) 1997-12-09 US disclosed
EP-0605735-B1 PROCESS FOR PRODUCING ALKADIENOL MITSUBISHI CHEM CORP (JP) 1997-11-05 EP disclosed
US-5557016-A HYDROXYLATION OF CONJUGATED ALKADIENES IN THE PRESENCE OF PALLADIUM CATALYSIS MITSUBISHI KASEI CORPORATION (JP) 1996-09-17 US disclosed
EP-0361304-B1 Method for producing alkadienols MITSUBISHI CHEM CORP (JP) 1996-02-21 EP disclosed
EP-0605735-A1 PROCESS FOR PRODUCING ALKADIENOL Mitsubishi Chemical Corporation (JP) 1994-07-13 EP disclosed
US-4990698-A Method for producing alkadienols MITSUBISHI KASEI CORPORATION (JP) 1991-02-05 US disclosed
EP-0361304-A2 Method for producing alkadienols Mitsubishi Chemical Corporation (JP) 1990-04-04 EP disclosed