Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886940 | 0.92 | MEN1 (0.35) | MEN1KMT2ACRHBPCRHR2TAS1R3 | |
| SCHEMBL4883276 | 0.88 | MEN1 (0.38) | MEN1KMT2ACRHBPCRHR2TAS1R3 | |
| SCHEMBL4788605 | 0.85 | MAPT (0.44) | MEN1KMT2ACRHBPCRHR2MAPT | |
| SCHEMBL4786501 | 0.84 | MEN1 (0.35) | MEN1KMT2ACRHBPCRHR2LMNA | |
| SCHEMBL3290470 | 0.84 | NTRK1 (0.42) | MEN1KMT2ACRHBPCRHR2MAPT | |
| SCHEMBL4787971 | 0.81 | MEN1 (0.38) | MEN1KMT2ACRHBPCRHR2F9 | |
| SCHEMBL4786438 | 0.79 | CNR1 (0.43) | MEN1KMT2ACRHBPCRHR2MAPT | |
| SCHEMBL4788948 | 0.74 | KMT2A (0.43) | MEN1KMT2ACRHBPCRHR2MAPT | |
| SCHEMBL3441891 | 0.72 | KMT2A (0.37) | MEN1KMT2AMAPTNTRK1LMNA | |
| SCHEMBL4897250 | 0.69 | CNR1 (0.44) | MEN1KMT2ATP53NTRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |