Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PYGL | P06737 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786438 | 0.89 | CNR1 (0.43) | KMT2AMEN1CRHBPCRHR2LMNA | |
| SCHEMBL4789019 | 0.85 | SMN1; SMN2 (0.41) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4787054 | 0.84 | LMNA (0.46) | KMT2AMEN1LMNARAB9ANPC1 | |
| SCHEMBL4787971 | 0.83 | MEN1 (0.38) | KMT2AMEN1CRHBPCRHR2LMNA | |
| SCHEMBL4886940 | 0.82 | MEN1 (0.35) | KMT2AMEN1CRHBPCRHR2LMNA | |
| SCHEMBL4786501 | 0.82 | MEN1 (0.35) | KMT2AMEN1CRHBPCRHR2LMNA | |
| SCHEMBL4750536 | 0.82 | HPGD (0.38) | KMT2AMEN1CRHBPCRHR2LMNA | |
| SCHEMBL4891786 | 0.80 | ALDH1A1 (0.42) | KMT2AMEN1LMNARAB9ANPC1 | |
| SCHEMBL3290470 | 0.77 | NTRK1 (0.42) | KMT2AMEN1CRHBPCRHR2LMNA | |
| SCHEMBL4747643 | 0.75 | FFAR2 (0.44) | LMNAALDH1A1L3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |