⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9433880 | 0.72 | — | — | |
| SCHEMBL5806873 | 0.70 | — | — | |
| SCHEMBL8465599 | 0.65 | — | — | |
| SCHEMBL11459831 | 0.61 | — | — | |
| SCHEMBL9256010 | 0.57 | — | — | |
| SCHEMBL15468834 | 0.56 | — | — | |
| SCHEMBL24376772 | 0.54 | SMN1; SMN2 (0.42) | — | |
| SCHEMBL1822544 | 0.54 | — | — | |
| SCHEMBL291795 | 0.54 | — | — | |
| SCHEMBL16522849 | 0.53 | KDM4E (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9421175-B2 | Prevention of retinopathy by inhibition of the visual cycle | LARSEN LARS MICHAEL (DK) | 2016-08-23 | — | — | US | disclosed |
| US-20080214668-A1 | USE OF RETINOIDS TO TREAT HIGH BLOOD PRESSURE AND OTHER CARDIOVASCULAR DISEASE | OREGON HEALTH AND SCIENCES UNIVERSITY (US) | 2008-09-04 | — | — | US | disclosed |
| US-20070249713-A1 | Prevention of Retinopathy by Inhibition of the Visual Cycle | LARSEN LARS M | 2007-10-25 | — | — | US | disclosed |
| US-20070154981-A1 | Insulin-producing cells derived from stem cells | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2007-07-05 | — | — | US | disclosed |
| EP-1727529-A2 | PREVENTION OF RETINOPATHY BY INHIBITION OF THE VISUAL CYCLE | Larsen, Lars, Michael (DK) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005087210-A2 | PREVENTION OF RETINOPATHY BY INHIBITION OF THE VISUAL CYCLE | LARSEN LARS MICHAEL (DK) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005045001-A2 | INSULIN-PRODUCING CELLS DERIVED FROM STEM CELLS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2005-05-19 | — | — | WO | disclosed |
| US-20030008919-A1 | Use of retinoids to treat high blood pressure and other cardiovascular disease | ROULLET JEAN-BAPTISTE (US) | 2003-01-09 | — | — | US | disclosed |
| US-6437003-B1 | STROKES | ROULLET JEAN-BAPTISTE (US) | 2002-08-20 | — | — | US | disclosed |
| US-5830760-A | IMMORTALIZED STEM CELL LINE | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1998-11-03 | — | — | US | disclosed |
| WO-1995004143-A1 | CREATING NOVEL HEMATOPOIETIC CELL LINES BY EXPRESSING ALTERED RETINOIC ACID RECEPTORS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1995-02-09 | — | — | WO | disclosed |