Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.45 |
| ▸ | JAK3 | P52333 | 5/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 2/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14020092 | 0.94 | JAK2 (0.41) | JAK2JAK3EGFRCDK4CCNE1 | |
| SCHEMBL14020291 | 0.90 | CDK2 (0.41) | JAK2JAK3CDK4CCNE1CDK2 | |
| SCHEMBL4623357 | 0.86 | JAK2 (0.48) | JAK2JAK3EGFRCDK4CCNE1 | |
| Hydrochloric Acid SCHEMBL4881375 | 0.86 | JAK2 (0.47) | JAK2JAK3EGFRCDK4CCNE1 | |
| SCHEMBL4708984 | 0.85 | AXL (0.46) | JAK2JAK3EGFRCDK4CCNE1 | |
| SCHEMBL4708985 | 0.85 | AXL (0.41) | JAK2CDK4UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL4621383 | 0.84 | HTR2A (0.49) | JAK2JAK3EGFRCDK4CCNE1 | |
| SCHEMBL4622912 | 0.84 | JAK2 (0.45) | JAK2JAK3EGFRCDK4CCNE1 | |
| SCHEMBL4882127 | 0.84 | CDK4 (0.43) | JAK2JAK3EGFRCDK4CCNE1 | |
| SCHEMBL14020086 | 0.81 | IGF1R (0.42) | JAK2JAK3EGFRCDK4CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269170-A1 | Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors | SANOFI-AVENTIS (FR) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269170-A1 | Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors | NFKBIA, IKBKB, IKBKE | JAK2 96/4885JAK3 303/4885EGFR 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.