Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708984 | 0.91 | AXL (0.46) | AXLUBE2MDCUN1D1ALDH1A1TSHR | |
| SCHEMBL4883484 | 0.85 | JAK2 (0.45) | AXLUBE2MDCUN1D1ALDH1A1TSHR | |
| SCHEMBL4753976 | 0.84 | TNK2 (0.42) | AXLTNK2JAK2 | |
| SCHEMBL14020092 | 0.80 | JAK2 (0.41) | AXLUBE2MDCUN1D1ALDH1A1TSHR | |
| SCHEMBL4789757 | 0.78 | PTGS2 (0.41) | AXLMAP4K1JAK2CDK4CCND1 | |
| SCHEMBL14020291 | 0.75 | CDK2 (0.41) | UBE2MDCUN1D1ALDH1A1TSHRMAPK1 | |
| SCHEMBL4753974 | 0.75 | AXL (0.46) | AXLMAPK1TNK2JAK2 | |
| SCHEMBL14625276 | 0.73 | ALDH1A1 (0.47) | ALDH1A1TSHRMAPK1NPSR1 | |
| SCHEMBL4623357 | 0.72 | JAK2 (0.48) | AXLJAK2CDK4BRD4FLT3 | |
| Hydrochloric Acid SCHEMBL4881375 | 0.72 | JAK2 (0.47) | AXLJAK2CDK4BRD4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904479-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006926-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2007-01-18 | — | — | WO | disclosed |